Mancozeb, an Inorganic-zinc dithiocarbamate is a typical fungicide with carbamate structure. It is chemically identified as ethylenebisdithiocarbamate (EBDC). It is commonly used for foliar application and seed treatment in agriculture. The present work was conducted to assess the protective effect of vitamin C against Mancozeb induced toxicity in the Testicular activity of adult albino rats. 9...

Mancozeb, an ethylene bis-dithiocarbamate, is widely used as a fungicide and exerts reproductive toxicity in vivo and in vitro in mouse oocytes by altering spindle morphology and impairing the ability to fertilize. Mancozeb also induces a premalignant status in mouse granulosa cells (GCs) cultured in vitro, as indicated by decreased p53 expression and tenuous oxidative stress. However, the pres...

Mancozeb, a mixture of ethylene-bis-dithiocarbamate manganese and zinc salts, is one of the most widely used fungicides in agriculture. Mancozeb could lead to mitochondria dysfunction, cellular anti-oxidation enzymes depletion and apoptotic pathways activation. Previous studies indicated the exposure of mancozeb through mother would lead to irregular estrous cycles, decreased progesterone level...

The use of fungicides is the continuous exercise particularly in orchard crops where fungal diseases, such as white root rot, have the potential to destroy horticultural crops rendering them unsaleable. In view of above problem, the present study examines the effect of different concentrations of mancozeb (0-2000 ppm) at different incubation periods for their harmful side effects on various mic...

Mancozeb is one member of ethylenebisdiothiocarbamate (EBDC) fungicides. This compound has a negligible vapor pressure, therefore it has a low potential to volatilize into the air. In water, mancozeb can be quickly hydrolyzed with a half-life of less than 2 days. The identified hydrolysis degradates are ethylenethiourea (ETU), ethyleneurea (EU) and ethylene bisisothiocyanate sulfide (EBIS). Man...

In order to reduce the level of dithiocarbamate fungicide mancozeb residues in blackcurrants, two different ozone treatment procedures were evaluated. The first one entailed washing the plant material with an aqueous solution of ozone. This ozone enriched water solution allowed for a 59% reduction of mancozeb residues, compared with the initial concentration. The latter method was based on the ...

Mancozeb, a fungicide of a manganese-zinc ethylenebisdithio-carbamate (EBDC), was administered by gavage at doses of 200, 400, 600 and 800 mg/kg/day to female virgin mice for 30 days. The mice were autopsied on 31st day. Mice were also treated with similar doses for a period of 30 days and the treatment was withdrawn for a further period of 30 days for reversible study. The mice were autopsied...

Pesticides are used in large amounts in agriculture and the evaluation of their toxic effects is of major concern to public and environmental health. The aim of the present study was to investigate the genotoxic potential of a commercial formulation of the fungicide mancozeb by the micronucleus test in bone marrow and the comet assay in total blood of Wistar rats. Adult male Wistar rats were tr...

Mancozeb is an ethylene-bis-dithiocarbamate (EBDC) fungicide. It is used in a wide range to control several of fungal diseases in field crops and fruits. Administration of mancozeb at a dose level of 1/10 LD50 3 times / week for six weeks induced marked histological and histochemical changes in thyroid gland of albino rat. The histological changes included dilation and congestion in blood vesse...

Mancozeb, a fungicide of ethylenebisdithiocarbamate group was orally administered at doses of 500, 600, 700 and 800 mg/kg body weight/day to normal virgin rats of Wistar strain for 30 days. The vaginal smear and body weight of the rats were recorded daily and rats were sacrificed on 31st day. Estrous cycle was effected by showing a significant decrease in the number of estrous cycle, duration o...