background: antibiotic therapies used in treatment of many diseases have adverse effects on fertility. this review analyzes previous comparative studies that surveyed the effects of two common groups of antibiotics on male fertility. objective: to evaluate histo-pathological effects of fluoroquinolones and aminoglycosides on sperm parameters and male reproductive tissue. materials and methods: ...

Reproductive tract abnormalities and male infertility have higher incidence in ADPKD patients than in general populations. In this work, we reveal that Pkd1, whose mutations account for 85% of ADPKD cases, is essential for male reproductive tract development. Disruption of Pkd1 caused multiple organ defects in the murine male reproductive tract. The earliest visible defect in the Pkd1(-/-) repr...

fertility in the male is dependent on the proper production of sperm cells. this process, called spermatogenesis is very complex and involves the synchronization of numerous factors. the presence of pro–inflammatory cytokines, tumor necrosis factor-alpha (tnf–α), interleukin–1 alpha (il–1 α) and interleukin 1 beta (il–1 β) cytokines in the male reproductive tract (testis, epididymis and sperm) ...

Problem: The sequential changes in the immunogenicity of spermatozoa in male reproductive tract and the effect of seminal vesicle secretions are long thought to act as central players in influencing immunological equilibrium in the male reproductive tract. Method of Study: Popliteal lymph nodes of mice were collected on the 8th day after sensitizing them with the testicular and epididymal sperm...

introduction toxoplasma gondii is one of the most important pathogen that has adverse effect on reproductive function. evidence acquisition recent studies revealed that infection with t. gondii not only affect female reproduction, also cause male reproductive impairment. in clinical studies, high prevalence of toxoplasmosis in sterile men has been reported. in animal models, toxoplasmosis is as...

This essay addresses the carboxylesterase redundancy in the male reproductive tract seemingly conserved across phyla. Evidence is provided which suggests that carboxylesterases are recruited by the male reproductive system in certain animal groups. These provide advantageous metabolic capabilities to sperm protection, sperm maturation, and sperm use. Rather than an archival record of the availa...