background: infertility is a health problem which affects about 10-20% of married couples. male factor infertility is involved approximately 50% of infertile couples. most of male infertility is regarding to deletions in the male-specific region of the y chromosome. objective: in this study, the occurrence of deletions in the azf region and association between infertility and paternal age were ...

Background Infertility is defined as failure in pregnancy after one year of unprotected intercourse. Several centers have reported different causes of infertility. The most common causes of infertility are: male factor such as sperm disturbance, female factor such as ovulation dysfunction and tubal factor, both male and female factor, and unexplained infertility .The aim of this study was to su...

Background: Recurrent abortion is defined as 3 or more pregnancy loses. It is estimated that between 0/5 to 3 percent of couples suffer from recurrent abortion. The male gamete contributes 50% of genomic Materials to the embryo and contributes as well as to placental and embryonic development. Oral antioxidant treatment has been reported to reduce the percentage of damaged spermatozoa and impro...

Background The human Y chromosome is essential for human sex determination and male germ cell development and maintenance. In 1996, Vogt et al. identified three recurrently deleted regions in Yq11 termed the azoospermia factor (AZF). The AZF region is subdivided into three non-overlapping sub-regions called AZFa, AZFb and AZFc and microdeletion in these regions is the most important etiology of...