Macrophage activation syndrome is a form of secondary hemophagocytic lymphohistiocytosis in the setting autoimmune diseases. It’s rare, hyperinflammatory complication requiring prompt institution therapy to prevent organ dysfunction and death. We report young female presenting with macrophage multiorgan failure diffuse alveolar hemorrhage inaugural systemic lupus erythematosus. The patient was ...

Introduction Macrophage activation syndrome (MAS) is a rare and life-threatening complication of Kawasaki Disease (KD) that is usually diagnosed at the same time or after KD. We report a case of MAS as the initial manifestation of KD. Case Report A previously healthy 3-year old girl was admitted to the pediatric infectious di...

We describe a case of adult-onset Still’s disease (AOSD) with secondary macrophage activation syndrome. AOSD is rare unknown origin. Rarely it’s complicated by syndrome, which life-threatening disorder. Because the diagnosis essential for exclusion and complications are life-threatening, it mandatory prompt extensive diagnostic workup treatment.

abstract: griscelli syndrome (gs) is a rare disease first described in 1978. it is inherited in autosomal recessive pattern. this disease is characterized by partial albinism, pigmentation dilution, cellular immunodeficiency, neurological involvement & uncontrolled phases of macrophage & lymphocyte activation. we report a 5 months old iranian girl presenting with silver-gray hair,eyelashes and ...

BACKGROUND Macrophage activation syndrome is a rare and life threatening complication of childhood rheumatic disorders. CASE CHARACTERISTICS 6-year-old male child with macrophage activation syndrome complicating systemic onset juvenile idiopathic arthritis. OBSERVATION He developed pericardial effusion, hyponatremia and deranged renal function. OUTCOME Improvement on intravenous cortico s...

macrophage activating syndrome (mas) is a life-threatening disease seen in autoimmune diseases including lupus erythematosus, rheumatoid arthritis, still's disease, polyarteritis nodosa. it is characterized by fever, pancytopenia, liver failure, coagulopathy, and neurologic symptoms and high serum ferritin. a 27 yr. old female patient was admitted in shahid mostafa khomeini hospital (tehra...

Macrophage activation syndrome is a rare and potentially life-threatening disease. It occurs due to immune dysregulation manifested as excessive macrophage proliferation, typically causing hepatosplenomegaly, pancytopenia and hepatic dysfunction. Here, we report an unusual case of macrophage activation syndrome presenting as dyspnea, as well as (reported here for the first time) high resolution...