نتایج جستجو برای: MUC1

تعداد نتایج: 2241  

Journal: :Journal of Immunology 2023

Abstract Cell-associated mucin 1(MUC1/Muc1) is a component of the mucus barrier in respiratory tract that acts as physical and signaling molecule. Our prior work shows MUC1 expression increased during influenza virus (IAV) infection human airway epithelial (HAE) cultures vitro. Here we further detail patterns report IAV-induced cytokines, including type I interferons (IFNs), trigger low-molecul...

Journal: :RSC chemical biology 2023

We unveil for the first time that pancreatic cancer cells (PANC-1) and secreted exosomes express MUC1 bearing cancer-relevant dynamic epitopes recognized specifically by an anti-MUC1 antibody (SN-131).

Objective(s): Breast cancer is one of the most common cancers in the world and is on the increase. MUC1 and HER2 as tumor-associated antigens (TAAs) are abnormally expressed to some extent in 75–80% of breast cancers.  In our present research, a novel chimeric MUC1-HER2 (HM) protein was designed and used to study whether an immune response can be generated against these TAAs. In vitro analysis ...

Journal: :Molecular cancer research : MCR 2015
Renee M Tholey Shruti Lal Masaya Jimbo Richard A Burkhart Fernando F Blanco Joseph A Cozzitorto Josh D Eisenberg Wei Jiang Christine A Iacobuzio-Donahue Agnieszka K Witkiewicz Melissa Glbert Charles J Yeo Jonathan R Brody Janet A Sawicki Jordan M Winter

UNLABELLED Mucin1 (MUC1) is overexpressed in pancreatic ductal adenocarcinoma (PDA) and is associated with tumor aggressiveness, suggesting that MUC1 is a promising therapeutic target for promoter-driven diphtheria toxin A (DTA). Endogenous MUC1 transcript levels were analyzed by quantitative PCR (qPCR) in multiple PDA cells (Capan1, HPAFII, Su.86.86, Capan2, Hs766T, MiaPaCa2, and Panc1). Expre...

Journal: :Pharmaceutics 2021

MUC1, the transmembrane glycoprotein Mucin 1, is usually found to be overexpressed in a variety of epithelial cancers playing an important role disease progression. MUC1 isoforms such as MUC1/Y, which lacks entire variable number tandem repeat region, are involved oncogenic processes by enhancing tumour initiation. MUC1/Y therefore considered promising target for identification and treatment ca...

Journal: :Journal of immunology 1998
R M Tempero M L VanLith K Morikane G J Rowse S J Gendler M A Hollingsworth

A C57BL/6 mouse transgenic for human MUC1 (MUC1.Tg) was developed to evaluate MUC1-specific tumor immunity in an animal that expresses MUC1 as a normal self protein. Previous studies showed that MUC1.Tg mice, challenged with syngeneic tumors expressing MUC1 (B16.MUC1), developed progressively growing MUC1-positive tumors, whereas wild-type C57BL/6 (wt) mice developed MUC1-negative tumors at a s...

Journal: :international journal of reproductive biomedicine 0
marzieh panahi azam soleimani mahmoud abdolrahman abdolrahman dezfoolian

background: acceptance of uterus and reaction between endometrium and embryo has an important role for implantation. muc1 an integral membrane mucin is expressed on the apical surface of uterine epithelial cells and could have effects on its receptivity. objective: the aim of this study was to evaluate the changes in muc1 expression of gravid mouse endometrium with and without hyperstimulation ...

2016
Michael Chalick Oded Jacobi Edward Pichinuk Christian Garbar Armand Bensussan Alan Meeker Ravit Ziv Tania Zehavi Nechama I. Smorodinsky John Hilkens Franz-Georg Hanisch Daniel B. Rubinstein Daniel H. Wreschner

Translation of mRNA in alternate reading frames (ARF) is a naturally occurring process heretofore underappreciated as a generator of protein diversity. The MUC1 gene encodes MUC1-TM, a signal-transducing trans-membrane protein highly expressed in human malignancies. Here we show that an AUG codon downstream to the MUC1-TM initiation codon initiates an alternate reading frame thereby generating ...

Journal: :Journal of immunology 2000
S Koido M Kashiwaba D Chen S Gendler D Kufe J Gong

Dendritic cells (DC) are potent APCs. In this study, murine bone marrow-derived DC were transfected with RNA encoding the MUC1 Ag that is aberrantly overexpressed in human breast and other carcinomas. The MUC1 RNA-transfected DC exhibited cell surface expression of MUC1 and costimulatory molecules. After injection at the base of the tail, the transfected DC were detectable in inguinal lymph nod...

2018
Yumei Li Changhua Zhou Jing Li Jiayu Liu Limin Lin Li Li Donglin Cao Qing Li Zhong Wang

Muc1 is one of the most studied tumor antigens. However, antibodies or antibody-toxin conjugates against Muc1 have not shown significant efficacy for tumors with Muc1 overexpression. In this study, we employed bispecific antibody approach to target Muc1 positive tumor cells. A novel bispecific antibody, Muc1-Bi-1, was constructed by linking single domain antibodies, anti-Muc1-VHH and anti-CD16-...

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