Purpose: Chronic stress represents a critical influence on ageing of Leydig cells in testis. We aimed to investigate expression changes of microRNA (miRNA) associated with stress-induced ageing in Leydig cells. Methods: Brown Norway rats were separated into three groups, young control group, stress group and age group. Physiological changes, including serum corticosterone and testosterone level...

Objective(s): To investigate the role of miR-22 in the efficacy of combined icotinib (BPI-2009H) and pemetrexed (LY-231514) on tumor growth and apoptosis in rats with non-small cell lung cancer (NSCLC).Materials and Methods: Rats were injected with HCC827 cells, which were transfected with anti-miR-22, followed by the treatment of BPI-20...

Non-alcoholic fatty liver disease is a high-risk factor for the morbidity and mortality of type 2 diabetes mellitus. Thus, we conducted meta-analysis to investigate whether microRNAs associated with non-alcoholic are their potential predict in individuals. We systematic literature search using PubMed, Cochrane library Embase databases. The about circulating microRNA levels nonalcoholic individu...

To figure out the pathway by which epigallocatechin gallate restrains angiogenesis and glycolysis in colorectal cancer through circular ribonucleic acid (actin gamma 2)/microRNA-370-5p axis. Detection of actin 2 microRNA-370-5p patient tissues cells vascular endothelial growth factor A was conducted. Cell viability proliferation, angiogenesis, glucose lactate were examined. Circular microRNA-37...

To explore the effect and molecular mechanism of total flavonoids Astragalus on apoptosis inflammation alveolar epithelial cells induced by tumor necrosis factor alpha. Human were divided into control group, alpha alpha+trifluoroacetic acid-low, acid-medium, acid-high alpha+anti-microRNA-NC alpha+microRNA-221 inhibitor acid-high+microRNA-NC acid-H+microRNA-221 mimic group. Real-time fluorescenc...

To investigate the effect of long non coding RNA MAGI2-antisense 3 on proliferation, invasion and migration cervical cancer cells underlying mechanism. SiHa were divided into plasmid cloning DNA group, DNA-MAGI2-antisense anti-microRNA-negative control anti-microRNA-31-5p 3+microRNAnegative group 3+microRNA-31-5p group; quantitative reverse transcription polymerase chain reaction was used to de...