Introduction: Vasodilatory stress is the standard paradigm for probing myocardial oxygenation (O2) changes due to coronary artery stenosis on the basis of BOLD MRI (1-3). However, since vasodilation is typically achieved with provocative stress, approaches that can identify the presence of stenosis on the basis of microvascular alterations at rest are highly desirable. It is known that myocardi...

The cytomegalovirus (CMV) UL97 kinase inhibitor maribavir (MBV) is undergoing clinical antiviral trials. Two clinical CMV isolates serially passaged in cell culture under MBV showed >20-fold increases in MBV resistance after the development of the UL97 mutation V353A in one of the isolates and of T409M in the other. Marker transfer studies confirmed that the V353A and T409M mutations conferred ...

Maribavir (MBV) inhibits Epstein-Barr virus (EBV) replication and the enzymatic activity of the viral protein kinase BGLF4. MBV also inhibits expression of multiple EBV transcripts during EBV lytic infection. Here we demonstrate, with the use of a BGLF4 knockout virus, that effects of MBV on transcription take place primarily through inhibition of BGLF4. MBV inhibits viral genome copy numbers a...

PURPOSE Myocardial blood volume (MBV) may provide complementary information about myocardial oxygen needs and viability. The aim of this study is to examine a Cardiovascular Magnetic Resonance (CMR) perfusion method to quantify the changes in MBV, in comparison with the radiolabeled 99mTc-Red-Blood-Cell (RBC) method. METHODS Normal mongrel dogs (n=12) were used in this study. Eight dogs were ...

Viral diseases are the most serious problem in shrimp culture as they result in severe production and economic losses. Monodon baculovirus (MBV) is a member of nucleopolyhedrosis virus (NPV) group that infect penaeid shrimps. Polymerase chain reaction (PCR) assays have been reported for specific and accurate detection of MBV. As variations in the strains of MBV would greatly affect the detectio...

T he presence of thrombus in the left atrium (LA) is an important factor in the selection of cases for percutaneous mitral balloon valvotomy (MBV). This is because of the danger of embolisation caused by manipulation of guidewires and balloon catheters. The American College of Cardiology/American Heart Association recommendations for MBV emphasise absence of LA thrombus. Transoesophageal echoca...

OBJECTIVE Insulin and contraction each increase muscle microvascular blood volume (MBV) and glucose uptake. Inhibiting nitric oxide synthase blocks insulin's but not contraction's effects. We examined whether contraction could augment the MBV increase seen with physiologic hyperinsulinemia and whether free fatty acid (FFA)-induced insulin resistance differentially affects contraction- versus in...

Reversible perfusion defects on (99m)Tc-sestamibi imaging during hyperemia are thought to occur due to myocardial blood flow (MBF) "mismatch" between regions with and without stenosis. We have recently shown that myocardial blood volume (MBV) distal to a stenosis decreases during hyperemia, resulting in a reversible perfusion defect on myocardial contrast echocardiography (MCE). In this study, ...

We employed and evaluated a new application of contrast-enhanced ultrasound for real-time imaging of changes in microvascular blood volume (MBV) in tissues in females, males, and rat. Continuous real-time imaging was performed using contrast-enhanced ultrasound to quantify infused gas-filled microbubbles in the microcirculation. It was necessary to infuse microbubbles for a minimum of 5-7 min t...

Prevalence status of white spot disease (WSD), caused by white spot syndrome virus (WSSV) and Monodon baculovirus (MBV), was studied in different prawn farms in North and South-24 paragana districts of West Bengal, specifically in the areas previously affected by WSD. In total 283 samples of giant tiger prawn Penaeus monodon, Indian white prawn P. indicus and giant freshwater prawn Macrobrachiu...