نتایج جستجو برای: MAPK/ERK and JAK/STAT pathway

تعداد نتایج: 16877886  

Journal: :Nephrology Dialysis Transplantation 2017

پایان نامه :دانشگاه آزاد اسلامی - دانشگاه آزاد اسلامی واحد علوم دارویی - پژوهشکده علوم 1392

purpose a metabolic abnormality such as obesity is a major obstacle in the maintenance of the human health system and causes various chronic diseases including type 2 diabetes, hypertension, cardiovascular diseases, as well as various cancers. this study was designed to summarize the recent scientific knowledge regarding the anti-obesity role of curcumin (diferuloylmethane), which is isolated f...

2013
Vishakha Sharma Adriana B. Compagnoni

The JAK (Janus kinase)-STAT (Signal transducer and activator of transcription) signal transduction pathway is a cascade of downstream cellular events initiated from outside of the cell through the cell surface to the DNA in the nucleus, causing transcription. The conventional modeling approach for signal transduction pathways involves solving ordinary differential equations (ODEs). We study her...

2015
Mark J. Kiel Anagh A. Sahasrabuddhe Delphine C.M. Rolland Thirunavukkarasu Velusamy Fuzon Chung Matthew Schaller Nathanael G. Bailey Bryan L. Betz Roberto N. Miranda Pierluigi Porcu John C. Byrd L. Jeffrey Medeiros Steven L. Kunkel David W. Bahler Megan S. Lim

Genomic analyses reveal recurrent mutations in epigenetic modifiers and the JAK–STAT pathway in Sézary syndrome Mark J. Kiel1,*, Anagh A. Sahasrabuddhe1,*,w, Delphine C.M. Rolland2,*, Thirunavukkarasu Velusamy1,*, Fuzon Chung1, Matthew Schaller1, Nathanael G. Bailey1, Bryan L. Betz1, Roberto N. Miranda3, Pierluigi Porcu4, John C. Byrd4, L. Jeffrey Medeiros3, Steven L. Kunkel1, David W. Bahler5,...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Jianping Wang Robert D Schreiber Iain L Campbell

Although signal transducer and activator of transcription 1 (STAT1) is an essential signaling molecule in many IFN-alpha-regulated processes, some biological responses to IFN-alpha can occur independently of STAT1. To establish the role of STAT1 in mediating the biological actions of IFN-alpha in the CNS, transgenic mice [termed glial fibrillary acidic protein (GFAP)-IFN-alpha] with astrocyte p...

2012
Francesco Passamonti

Polycythemia vera (PV) is a clonal disorder characterized by unwarranted production of red blood cells. In the majority of cases, PV is driven by oncogenic mutations that constitutively activate the JAKSTAT signal transduction pathway, such as JAK2 V617F, or exon 12 mutations or LNK mutations. Diagnosis of PV is based on the WHO criteria. Diagnosis of post-PV myelofibrosis is established accord...

Journal: :مجله علوم اعصاب شفای خاتم 0
shahin mohammad sadeghi a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran. b. department of plastic and reconstructive surgery, shahid beheshti university of medical sciences, tehran, iran. sajad sahab negah a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran. b. histology and embryology group, basic science department, veterinary medicine faculty, shiraz university, shiraz, iran. hadi kazemi a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran. b. pediatric department, shahed university, tehran, iran. zabihollah khaksar histology and embryology group, basic science department, veterinary medicine faculty, shiraz university, shiraz, iran. hadi aligholi shefa neuroscience research center, khatam alanbia hospital, tehran, iran. mostafa modarres mousavi shefa neuroscience research center, khatam alanbia hospital, tehran, iran.

adenosine acts as neuromodulator in the brain, which its involvement in a wide range of brain processes and diseases has been studied, such as epilepsy, sleep, anxiety, panic disorder, alzheimer’s disease, parkinson’s disease and schizophrenia. adenosine receptors have been detected: a1r, a2ar (a2ar), a2br, and a3r. a1r and a2r inhibit camp production, while a2ar and a2br stimulate camp product...

Journal: :iranian journal of pharmaceutical research 0
yong peng yanshan university zhan-zhao fu the first hospital of qinhuangdao town cong-shan guo yanshan university yan-xia zhang yanshan university bin jiang yanshan university bin jiang yanshan university

the objective of this study was to observe the apoptosis-inducing effect and mechanism of baicalin on human cervical cancer hela cells. the inhibitory effect of baicalin on the growth of hela cells was measured by mtt assay, and cell proliferation and migration was analyzed by cell scratch assay. morphological changes of apoptotic cells were viewed by the light microscope and electron microscop...

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