objective(s): although tumor necrosis factor-related apoptosis-inducing ligand (trail) can selectively induce apoptosis in tumor cells, more than half of tumors including non-small cell lung cancer (nsclc) exhibit trail-resistance. the purpose of this study was to determine whether subtoxic-dose cisplatin and trail could synergistically enhance apoptosis on nsclc cells and investigate its under...

introduction radon is a colorless and tasteless gas which exists in most soils. it is a substance that poses a potential risk for lung cancer in case a person is exposed to high levels over long periods of time. the environmental protection agency (epa) estimates that 90% of lung cancers per year are caused by radon. the aim of this paper is to estimate the absorbed doses of 222rn by mcnpx simu...

Background: A new treatment approach for most patients who have undergone early stage non-small-cell lung carcinoma (NSCLC), is wedge resection plus permanent implant brachytherapy. However, the specification of dose to medium at low energies especially in heterogeneous lung is unclear yet.Objective: The present study aims to modify source strength for different configurations of 125I and 103...

background: prediction of the absorbed dose in irradiated volume plays an important role in the outcome of radiotherapy. application of small fields for radiotherapy of thorax makes the dose calculation process inaccurate due to the existence of electronic disequilibrium and intrinsic deficiencies in dose calculation algorithms. to study the lung absorbed dose in radiotherapy with small fields,...

Introduction: Boron neutron capture therapy (BNCT) is recommended to treat the glioblastoma tumor. It is well known that neuron beams are more effective treatment than photon beams to treat hypoxia tumors due to interaction of neutron with nucleus and production of heavy particles such as 7Li and alpha particle. In this study to evaluate the suitability of BNCT for treating of ...

Background: Intensity Modulated Radiotherapy (IMRT) can improve radiotherapy (RT) results by improving healthy tissue sparing. Additionally, IMRT provides more consistent dose deliveries and suppresses secondary tumor formation. RT is a principal treatment in breast cancer (BC). Aim: To evaluate the outcome of the Radiotherapy Plans (RTP) that use IMRT technique to left breast and other organs,...

background: to determine which radiotherapy parameters are associated with the tumor response of locally advanced non-small cell lung cancer (nsclc) patients undergoing concurrent chemoradiotherapy. materials and methods: thirty one patients with iiia/iiib nsclc underwent chemoradiotherapy with a median dose of 63 gy. on our actual treatments, we made radiotherapy planning to cover the planning...

Background: Accurate dose calculations in small beamlets and lung material have been a great challenge for most of treatment planning systems (TPS).  In the current study, the dose calculation accuracy of TiGRT TPS was evaluated for small beamlets in water and lung phantom by comparison to Monte Carlo (MC) calculations. Materials and Methods: The head of Siemens Oncor-impression linac...

Introduction: Internal exposure to radon gas progeny can lead to serious biologic damages to the lung tissue. The aim of this study was to evaluate the absorbed dose by lung tissue due to the exposure from short-lived radioactive products of radon (222Rn) decay using Monte Carlo simulation. Material and Methods: A lung equivalent p...

Background: Breast cancer is becoming more frequently diagnosed at early stages with improved long term outcomes. Radiation-related heart disease and lung cancer can occur following radiotherapy for breast cancer. The aim of this study was to evaluate some dosimetric parameters of heart and lung during whole breast radiotherapy. Methods:Twenty five consecutive...