نتایج جستجو برای: Losartan

تعداد نتایج: 3767  

Effat Souri, Hassan Farsam, Hassan Jalalizadeh, Mehdi Ansari,

A rapid and sensitive HPLC method was developed for determination of losartan in plasma. Losartan was extracted from plasma by a two-step extraction procedure using chloroform as extracting solvent in acidic medium. HPLC analysis was performed on a cyano reversed-phase column using phosphate buffer (pH 4.3), acetonitrile (750:250, v/v) as mobile phase with a flow rate of 0.9 mL/min. Sodium dicl...

Journal: :research in cardiovascular medicine 0
yan-min xu department of cardiology, tianjin medical university, tianjin, republic of china; department of cardiology, tianjin medical university. tianjin, republic of china. tel: +86-2288328339, fax: +86-2228261158 deepak sharma department of cardiology, tianjin medical university, tianjin, republic of china guang-ping li department of cardiology, tianjin medical university, tianjin, republic of china ya-nan zhao department of cardiology, tianjin medical university, tianjin, republic of china

materials and methods: 32 new zealand rabbits were randomly divided into three groups: control group, high-cholesterol group and losartan group. the level of weights, serum lipid levels and inflammatory factors, such as il-6 and hs c-reactive protein were detected before the losartan intervention and two months after the losartan intervention respectively. the content of angii was detected on l...

Background and purpose: Crocin as a carotenoid exert anti-inflammatory, anti-oxidant, and anti-diabetic effects. There is an increasing prevalence of diabetes mellitus and its complications and patients are more interested in natural product treatments. This study aimed at investigating the efficacy of crocin and losartan alone and combination of the two drugs on insulin resistance and protecti...

Journal: :International Heart Journal 2021

High-mobility group box 1 (HMGB1) is increased in the myocardium under pressure overload (PO) and involved PO-induced cardiac remodeling. The mechanisms of upregulation HMGB1 expression have not been fully elucidated. In present study, a mouse transverse aortic constriction (TAC) model was used, an angiotensin II (Ang II) type (AT1) receptor inhibitor (losartan) or Ang 2 (AT2) (PD123319) admini...

خیاط نوری, میرهادی, دوستار, یوسف, موسوی, غفور, نشاط قراملکی, مهرداد,

flow. Losartan is angiotensin II receptor I (AT1) antagonist and is used for treatment of congestive heart failure and hypertension. It is widely recognized that Losartan has organ protective nature and most effective for organ damage progressing. The aim of this study was to evaluate the effect of Losartan on apoptosis in renal tissue after unilateral ureteral obstruction in rat. Materials and...

Journal: :iranian journal of medical sciences 0
izadpanah gheitasi department of physiology, school of medicine, shiraz university of medical sciences, shiraz, iran seyed mostafa moosavi department of physiology, school of medicine, shiraz university of medical sciences, shiraz, iran

background: previous study by the authors showed that a-tocopherol prevents oxidative stress but would not improve depressed excretory variables in post-obstructed kidney (pok) after release of 24-h unilateral ureteral obstruction (uuo). this study is a supplementary investigation on the effects of a-tocopherol combined with an antagonist of angiotensin-ii type-1 (at1) receptor on renal dysfunc...

M Ansari M Ebrahimi M Kazemipour

Background & Aims: Losartan is a non-peptide potent antihypertensive agent that acts through blocking angiotensin II receptors. Hyzaar® is a combination product that contains two drugs, losartan and hydrochlorothiazide, used to lower high blood pressure. There are some reports regarding simultaneous measurement of the drugs in pharmaceutical and biological samples which includes HPLC, CE, CEC, ...

Izadpanah Gheitasi Seyed Mostafa Moosavi

Background: Previous study by the authors showed that a-tocopherol prevents oxidative stress but would not improve depressed excretory variables in post-obstructed kidney (POK) after release of 24-h unilateral ureteral obstruction (UUO). This study is a supplementary investigation on the effects of a-tocopherol combined with an antagonist of angiotensin-II type-1 (AT1) receptor on renal dysfunc...

Introduction: Inhibition of renin angiotensin system represents an important approach in the management of cardiovascular diseases. The aim of this study was to explore the effects of pretreatment with non-hypotensive dose of angiotensin converting enzyme (ACE) inhibitor, ramiprilat and angiotensin type 1 (AT1) receptor blocker, losartan on myocardial infarct size and arrhythmias in a rat mo...

Journal: :Bangladesh Medical Research Council bulletin 2010
M Zakirul Islam M Sayedur Rahman

The study was conducted to evaluate the anti-atherogenic potential of losartan and to assess the effects of hydrochlorothiazide and indapamide on losartan activity in rat. Cholesterol diet (0.5%) for 12 weeks led to significant hyperlipidemia, increased body weight and oxidative stress in erythrocyte. While, losartan, hydrochlorothiazide and indapamide treatment continued for next 12 weeks, los...

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