introduction: to study the effect of gallic acid (ga) on hippocampal long-term potentiation (ltp) and histological changes in animal model of alzheimer disease (ad) induced by betaamyloid (aβ). methods: sixty-four adult male wistar rats (300±20 g) were divided into 8 groups: 1) control (cont); 2) ad; 3) sham; 4-7) ad+ga (50, 100, and 200 mg/kg for 10 days, orally) or vehicle, 8) cont+ga100, aβ ...

introduction: stress is associated with neurological and cognitive disorders. it has been suggested that doxepin, in addition to its influence on the content of neurotransmitters, has probable neuroprotective effects as well. therefore, the aim of this study was to investigate the effects of doxepin on synaptic plasticity and brain-derived neurotrophic factor (bdnf) gene expression in the rat h...

long-term potentiation (ltp) is a reflection of synaptic plasticity that induced by specific patterns of synaptic activity and has an important role in learning and memory. the first clue of the potential role of glutamate receptors in ltp was in 1991 with the observation that the mglur agonists 1-amino-1, 3-cyclopentanedicarboxylic acid (acpd), increased ltp. studies have shown that acpd induc...

the effect of endogenous serotonin on long-term potentiation (ltp) in region cai was studied by blocking 5-ht2 receptors with ketanserin in rat hippocampal slices. such a block significantly en-hanced long-term potentiation of the cai population spike induced by high frequency stimulation of the schaffer collateral/ commissural pathway. this implies that serotonin acts on 5-ht2 receptors in cai...

The term synaptic plasticity points to a series of persistent changes related to the activity of synapses. Long-term potentiation (LTP) is a reflection of synaptic plasticity that has an important role in learning and memory. LTP is a long-lasting increase of synaptic activity due to enhancement of excitatory synaptic transmission after a high-frequency train of electrical stimulations. Differe...

introduction: previous studies indicate that exercise influences cognitive function. nevertheless, considering that exercise in animal study can be voluntary, or forced, effects of exercise (specially forced exercise) on learning and memory abides as a matter of controversy. the present study aimed to investigate the effects of treadmill exercise on ltp in the dentate gyrus of rats. methods: th...

introduction: over the last decade, exposure to non-ionizing electromagnetic waves due to base station antenna has increased. this in vivo study was planned for evaluating the effects of whole-body exposure to 950 mhz field of gsm mobile phone system on rat dentate gyrus long-term potentiation. materials and methods: 24 naive male wistar rats (3 month old, 225|¡|25 g) were randomly divided in t...

introduction: over the last decade, exposure to electromagnetic waves due to base station antennas has increased. this study was planned to evaluate the effects of different electrical field strengths with 950 mhz waves of the gsm mobile phone system on the excitatory postsynaptic potentiation (epsp) slope of the dentate gyrus long-term potentiation (ltp). material and methods: twenty four naiv...

The effect of endogenous serotonin on long-term potentiation (LTP) in region CAI was studied by blocking 5-HT2 receptors with ketanserin in rat hippocampal slices. Such a block significantly en-hanced long-term potentiation of the CAI population spike induced by high frequency stimulation of the schaffer collateral/ commissural pathway. This implies that serotonin acts on 5-HT2 receptors in CAI...

Synaptic plasticity in the central nervous system (CNS) of mammals has been discussed for many years. Several forms of synaptic plasticity of mammal’s CNS have been identified, such as those that occur in long-term potentiation (LTP). Different types of LTP have been observed in distinctive areas of the CNS of mammals. The hippocampus is one of the most important areas in the CNS that pla...