conclusions hepatic shock is detected in ill patients, especially those with hemodynamic disorders. it can be prevented by early treatment of underlying disease. there is no definite treatment for hepatic shock and should be managed conservatively. hepatic shock in patients can increase the mortality rate. results different causes can lead to hepatic shock. most of these causes can be prevented...

conclusions any discrepancy between histopathologic changes in time-zero biopsies and pattern of early liver laboratory alterations may be considered as a warning for causes other than pri. objectives the aim of this study was to show the correlation between histopathologic changes of pri and the alterations in liver tests in the early post-transplantation period. materials and methods between ...

background:methotrexate (mtx) is one of the most commonly used disease-modifying antirheumatic drugs in the treatment of rheumatoid arthritis (ra) which can be associated with toxic effects on different organs. this study was designed to investigate the hepatotoxic effects in ra patients treated with mtx. methods: in this cross-sectional observational study, ra patients who received standard do...

introduction drug-induced liver injury is a frequent cause of hepatic dysfunction. several drugs have been identified to cause autoimmune hepatitis (aih). environmental chemicals are capable of triggering a certain degree of liver injury. however, toxin induced aih is rare. conclusions chronic (long-term) exposures to dichlorvos can lead to aih. a detailed inquiry of medical history and liver b...

conclusions in conclusion, we have shown that vitamin c administration provides protection against csa-induced injury in rat liver function and may have hepatoprotective role in the patients experiencing csa treatment. background cyclosporine a (csa) is an important immunosuppressive agent; however, its clinical use is limited by several side effects such as hepatotoxicity. vitamin c (ascorbic ...

conclusions hepatotoxicity of halogenated inhalational anesthetics has been well documented in available literature. halothane-induced liver injury was extensively acknowledged; however, the next generation halogenated anesthetics have different molecular structures and associated with less hepatotoxicity. although anesthesia-induced hepatitis is not a common occurrence, we must consider the as...

Background: Liver is one of the target organs for COVID-19 infection. The liver damage in critically ill patients was investigated in previous studies, but there is no available data about liver injury in mild to moderate form of infection with COVID019. In this study, we estimated the prognostic factors related to liver injury in NON-ICU admitted patients infected with COVID-19. Methods: in t...

introduction and objectives: tuberculosis (tb) still remains a major health concern both in developing and developed countries. the rate of the liver injury due to anti-tb drugs in developed countries has been reported up to 4%. the goal of this study is to assess the rate and risk factors for anti-tuberculosis drug-induced liver injury (dili). also, a model has been designed to predict dili in...

the present study aimed at investigating the beneficial effects of co-administering granulocyte colony–stimulating factor (g-csf) and stem cell factor (scf) in a model of chronic liver injury induced by thioacetamide (taa). biochemical and histopathology- cal examinations were performed on serum and liver specimens. at the end of the treatment period, the rats were anesthetized with ether, seru...

the incidence of drug induced liver injury (dili) is about 1/1000 to 1/10000 among patients who receive therapeutic drug doses. drug induced hepatotoxicity is a major cause of acute and chronic liver disease. the severity of liver damage ranges from nonspecific changes in liver structure to acute liver failure, cirrhosis and liver cancer. some common agents that can cause liver injury are aceta...