Nicolau syndrome also known as Embolia cutis medicamentosa and Livedoid dermatitis is a rare complication characterized by tissue necrosis that occurs after injection of medicines. We describe a case of late development of Nicolau syndrome following intra-articular infiltration with corticosteroid.

Nicolau syndrome (livedoid dermatitis) is a rare adverse reaction of a still largely unidentified pathogenesis at the site of intramuscular drug injection. The typical presentation is pain around the injection site soon after injection, followed by erythema, livedoid patch, haemorrhagic patch, and finally necrosis of skin, subcutaneous fat, and muscle tissue. The phenomenon has been related to ...

Introduction Livedoid and gangrenous dermatitis is a rare posttherapeutic accident, produced by intravenous, intramuscular or intra-arterial drug injection under an oily or suspension form. In the first stage, artery and branches embolization occurs or there is wall irritation. In the second stage thrombosis or arterial spasms follow and acute ischemia syndrome of segmental skin occurs. The ext...

we report a case of nicolau syndrome in a 15 months old girl following of an intramuscular injection of penicillin 6.3.3 in her left buttock. this case is unique because she developed compartment syndrome in her left calf far from her injection site. her toe’s tips gangrened in the course of her ailment. we hypothesized that the compartment syndrome might be produced by a probable intra-arteria...

Nicolau syndrome is a rare complication of intramuscular injection consisting of ischemic necrosis of skin, soft tissue, and muscular tissue that arises locoregionally. The characteristic pattern is pain around the injection site, developing into erythema, a livedoid dermatitis patch, and necrosis of the skin, subcutaneous fat, and muscle tissue. Three patients were injected with drugs (diclofe...

Livedoid vasculopathy (atrophie blanche) is a form of thrombotic vasculopathy. It is characterized by small ulcers that become crusted, and heal after several months to produce white atrophic scars. The most commonly affected sites are the lower legs, in particular the dorsum of the feet and ankles. To date, the dermoscopic features of livedoid vasculopathy have not been clearly described in th...

BACKGROUND Livedoid vasculitis is a chronic dermatological problem with an unclear etiology. Clinical findings are petechiae with painful ulcers in both lower extremities, which heal to become hyperpigmented and porcelain-white satellite lesions. There are only a few reported cases of livedoid vasculitis presenting in combination with peripheral neuropathy. CASE REPORT We report the first cas...

1. Koller S, Kränke B. Nicolau syndrome following subcutaneous glatiramer-acetate injection. J Am Acad Dermatol. 2011;64:16—7. 2. Kim KK. Nicolau syndrome in patient following diclofenac administration: a case report. Ann Dermatol. 2011;23: 501—3. 3. Gaudez C, Regnier S, Aractingi S, Heinzlef O. Livedolike dermatitis (Nicolau’s syndrome) after injection of Copolymer-1 (Glatiramer acetate). Rev ...

We describe a new method for treating livedoid vasculopathy. The typical presentation of livedoid vasculopathy includes chronic, recurrent painful ulcers, satellite scar-like atrophy and telangiectasia involving the lower extremities. Histologically, these lesions show areas of ulceration and dermal vessel occlusion without frank inflammatory cell infiltration. There is currently no satisfactor...