2.2. THEORETICAL BACKGROUND OF HPLC ........................................................................................ 65 2.2.1. Direct measurement of lipophilicity by chromatographic methods ....................68 2.2.2. Measurements of lipophilicity using isocratic chromatographic retention ......70 2.2.3. Measurements of lipophilicity using gradient chromatographic retention ......73 2...

In this work, we calculated the several physico chemical properties containing of solubility (byVCL), lipophilicity (by milinspiration), dipole and quadrupole moments (by Density FunctionalTheory) for 7 AZT analogs, and compared these parameters with inhibition assays of them. It isresulted; cytotoxicity of these drugs is related with their lipophilicity inversely. With using of thisresult, for...

Abstract Bacterial DNA gyrase and topoisomerase IV control the topological state of during replication represent important antibacterial drug targets. To be successful as candidates, newly synthesized compounds must possess optimal lipophilicity, which enables efficient delivery to site action. In this study, retention behavior twenty-three previously dual inhibitors was tested in RP-HPLC syste...

The retention behavior and lipophilicity parameters of some antiphychotics were determined using reversed-phase thin layer chromatography. Quantitative structure-activity relationships studies have been performed to correlate the molecular characteristics of observed compounds with their retention as well as with their chromatographically determinated lipophilicity parameters. The effect of dif...

The lipophilicity of anticancer and immunosuppressant active 1,8-diazaphenothiazine derivatives ( 1: - 16: ) has been investigated. Their lipophilicity (RM0 and log PTLC) was determined by reversed-phase thin-layer chromatography with mixtures of acetone and TRIS buffer as mobile phases. The parameter RM0 and specific hydrophobic surface area b were significantly intercorrelated showing congene...

in this assay, the evaluation of lipophilicity of four ace-inhibitors and hydrochlorothiazide (hctz) with rp-tlc on cellulose layers was described using three binary solvent systems. the selected ace inhibitors had sufficiently different structures which can indicate the method suitability for their lipophilicity evaluation as the model substances in comparison with hctz. in addition, the linea...

in this work, we calculated the several physico chemical properties containing of solubility (byvcl), lipophilicity (by milinspiration), dipole and quadrupole moments (by density functionaltheory) for 7 azt analogs, and compared these parameters with inhibition assays of them. it isresulted; cytotoxicity of these drugs is related with their lipophilicity inversely. with using of thisresult, for...

Fluorescent model substances of increasing lipophilicity (Oregon Green) 488, Bodipy, FL C5 and Bodipy 564/570 C5) were selected to enable the visualization in the skin using confocal laser scanning microscopy. After measuring the penetration for 18 h, the nonfixed human scalp skin was imaged from the bottom parallel to the stratum corneum and in a cross-section view perpendicular to the skin su...

Department of Chemistry, Avinashilingam Deemed University for Women, Coimbatore641 043 ABSTRACT Lipophilicity which plays an important role in research into the structure-activity relationship of drug action has been theoretically predicted for few chromen-2-ones and chromen-2-thiones using commercial software HyperChem 7.0 and an internet computational software ALOGPS 2.1. In the compounds ana...