Background & Aims: Lipotoxicity is the process through which accumulation of lipid intermadiates leads to cellular dysfunction. The worldwide prevalence of cardiovascular diseases has been increased dramatically due to lipotoxicity. According to the peformed studies, saturated and unsaturated fatty acids differ significantly in their contributions to lipotoxicity. It has been r...

background and objectives:wild sage(salvia macrosiphon boiss.) known as “marvak” in persian is one of the polymorphic and abundant plants of lamiaceae. the plants whole seeds usually soaked or boiled in hot water are widely used for inflammatory ailments in folk medicine. documents have shown that there is scant information on the chemical constituents of this plant seeds. the current study was...

background & aim: purslane (portulaca oleracea l.), belongs to the portulacaceace family, grows in many parts of iran. results of previous studies were indicated purslane is a rich source of essential fatty acids of omega-3 and omega-6.  portulaca oleracea is a widespread weed, being the eighth common plants of the world. the aim of current study was to compare the essential fatty acids com...

To investigate the underlying mechanisms of C18 fatty acids (stearic acid, oleic acid, linoleic acid and α-linolenic acid) on mast cells, we measured the effect of C18 fatty acids on intracellular Ca(2+) mobilization and histamine release in RBL-2H3 mast cells. Stearic acid rapidly increased initial peak of intracellular Ca(2+) mobilization, whereas linoleic acid and α-linolenic acid gradually ...

High levels of linolenic acid (80 g kg(-1)) are associated with the development of off-flavors and poor stability in soybean oil. The development of low linolenic acid lines such as RG10 (20 g kg(-1) linolenic acid) can reduce these problems. The level of linolenic acid in seed oil is determined by the activities of microsomal omega-3 fatty acid desaturases (FAD3). A major linolenic acid QTL (>...

PURPOSE OF REVIEW This review critically evaluates current knowledge of alpha-linolenic acid metabolism in adult humans based on the findings of studies using stable isotope tracers and on increased dietary alpha-linolenic acid intake. The relative roles of alpha-linolenic acid and of longer-chain polyunsaturated fatty acids in cell structure and function are discussed together with an overview...