membrane permeability and p-glycoprotein (p-gp) efflux system are regulating factors in the drug brain penetration. recently, some drug delivery systems have been developed to overcome these limitations. in this study, metoclopramid has been encapsulated in plga nanoparticles using the emulsification/solvent evaporation technique for in vitro evaluation of the effect of plga nanoparticles on bb...

This paper investigates a multi-period rectilinear distance 1-center location problem considering a line-shaped barrier, in which the starting point of the barrier follows the uniform distribution function. In addition, the existing points are sensitive to demands and locations. The purpose of the presented model is to minimize the maximum barrier distance from the new facility to the existing ...

We discuss the role of break-up process of a loosely-bound projectile in subbarrier fusion reactions. Coupled-channels calculations are carried out for Be + Pb and 4,6He + U reactions by discretizing in energy the particle continuum states. Our calculations show that the coupling to the break-up channel has two effects, namely the loss of flux and the dynamical modulation of fusion potential. T...

Barrier coverage of a wireless sensor network is a critical issue in military and homeland security applications, aiming to detect intruders that attempt to cross the deployed region. While a range of problems related to barrier coverage have been investigated, little effort has been made to explore the effects of different sensor deployment strategies and mechanisms to improve barrier coverage...

The blood-air barrier in the lung consists of the alveolar epithelium, the underlying capillary endothelium, their basement membranes and the interstitial space between the cell layers. Little is known about the interactions between the alveolar and the blood compartment. The aim of the present study was to gain first insights into the possible interplay between these two neighbored cell layers...

This paper considers the Tchebychev distance for a facility location problem with a probabilistic line barrier in the plane. In particular, we develop a mixed-integer nonlinear programming (MINLP) model for this problem that minimizes the total Tchebychev distance between a new facility and the existing facilities. A numerical example is solved to show the validity of the developed model. Becau...