brucellosis is a major health problem in many parts of the world, particularly in the mediterranean and middle east. very few data on the frequency and diversity of haematological abnormalities occurring in brucellosis have been reported. in the present study 85 patients with brucellosis in imam khomeini hospital during 1997-2002 were investigated retrospectively to determine the haematological...

abstract background brucella mellitensis, the most invasive strain of brucella, is the predominant strain of genus brucella in iran. it causes variety of hematological abnormalities some of which are frequent and causes difficulties in diagnosis. objective to find hematological abnormalities of brucellosis in hospitalized patients in an endemic area. materials and methods a retrospective review...

OBJECTIVE Chemotherapy is the standard treatment for small-cell lung cancer (SCLC), and leukopenia is a common side effect. This study assesses whether chemotherapy-induced leukopenia is a predictor of efficacy and whether it is associated with the survival of SCLC patients. METHODS A retrospective analysis was conducted on data from 445 patients with SCLC who received standard chemotherapy f...

background& objectives: inspite of intensive worldwide efforts to reduce its transmission, malaria remains the most serious and widespread protozoal infection of humans. it is a protozoan disease transmitted by the bite of infected female anopheles mosquito. malaria has long featured prominently in the grey area between parasitology and hematology. this study has been performed to evaluate ...

Platinum-based chemotherapy is the front-line treatment in patients with metastatic non-small cell lung cancer (NSCLC). Leukopenia is one of its common side effects. The aim of this study was to analyze the association between the grade of platinum-based chemotherapy induced leukopenia and the clinical outcome of NSCLC patients. Three hundred nine patients with metastatic NSCLC, treated with pl...

Because adenine is effective for managing cases of radiation-induced and drug-induced leukopenia, it may be effective in cases of antipsychotic-induced leukopenia and neutropenia. Here, we report our experience with patients with leukopenia and neutropenia caused by an antipsychotic overdose or discontinuation of lithium carbonate, in whom adenine administration ameliorated the white blood cell...

Thiopurines such as azathioprine (AZA) and 6-mercaptopurine are frequently used for the treatment of inflammatory bowel diseases. Patients with low or absent thiopurine S-methyltransferase (TPMT) activity, resulting in high 6-thioguanine nucleotide levels, have an increased risk of developing leukopenia. Alternatively, certain viral infections could induce leukopenia. We present the case of an ...