CONTEXT The presentation of pancreatic cancer with a leukemoid reaction is rare with no prior reports in the English language literature. CASE REPORT We report a case of advanced pancreatic cancer presenting with leukemoid reaction. Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor levels were normal while interleukin-6 was elevated. The patient had no...

Leukemoid reaction is defined as reactive leukocytosis exceeding 40 × 10⁹/l, with a significant increase in early neutrophil precursors, and can be a paraneoplastic manifestation of various malignant tumors. Leukemoid reaction is a sign for poor prognosis in solid tumors so is sarcomatoid renal cell carcinoma (SRCC) when compared to more differentiated histologies. Here, we are reporting two ca...

lated to play an important role in the pathogenesis of PG. A marked persistent leukocytosis (White blood cells, >50 000/lL) with bandemia, when the cause is other than leukemia, defines a leukemoid reaction. The major causes of leukemoid reactions include severe infections, intoxications and malignancies. A previous report showed that severe PG with extensive ulceration may have leukocytosis. T...

BACKGROUND To the Authors' knowledge, the literature regarding leukemoid reaction in patients with malignant bone tumor is sparse, and most of patients with leukemoid reaction have poor prognosis. AIM To study the leukemoid reaction in malignant bone tumor patients. MATERIALS AND METHODS A total of 105 consecutive malignant bone tumor patients with a white blood cell count > 50,000/microL w...

Sir, Paraneoplastic syndromes are defined as nonmetastatic systemic effects that accompany malignant disease. These syndromes may occur in up to 10-15% of malignancies. A few paraneoplastic syndromes have been reported in metastatic transitional cell carcinoma including hypercalcemia, thrombocytosis, eosinophilia, nephrotic syndrome, acanthosis nigricans, dermatomyositis, polymyositis, and leuk...

Historical background and past knowledge: The term ‘leukemoid reaction’ was coined by Krumbhaar, in 1926, to describe the leukemia-like blood picture that was found in several non-leukemic conditions [3]. The diagnostic criteria included a total leukocyte count (TLC) of more than 50000/mm3 and/or the presence of immature leukocytes (mostly myelocytes or their equivalents) in the peripheral bloo...

A 7 year-old male presented with recurrent fever, cough and respiratory distress for over last 2 years. Based on extremely high eosinophil count, high Immunoglobulin E, increase in eosinophilic precursors in bone marrow, and positive antigen test for Wuchereria bancrofti, a diagnosis of Tropical Pulmonary Eosinophilia with Eosinophilic Leukemoid Reaction was made. Complete recovery was achieved...