BACKGROUND Historically, leishmanization is the most effective protective measure against Cutaneous Leishmaniasis (CL), CL lesion induced by leishmanization sometimes takes a long time to heal. Manipulation of leishmanization inoculums needed to induce a mild and acceptable CL lesion. The aim of this study was to explore if liposomal form of CpG ODN (Cytosin phosphate Guanin Oligodeoxynucleotid...

a list of 28 patients is given in whom the duration of the sore at the site of leishmanization has been 3 to 7 years. the problem of cases of cutaneous leishmanjasis with long duration as a complication of leishmanization is discussed. although this complication is very rare, i.e. a few hundreds among more than 2 million people inoculated, its effect on the leishmanization program has been cons...

Cutaneous leishmaniasis caused by Leishmania major is an emergent, uncontrolled public health problem and there is no vaccine. A promising prophylactic approach has been immunotherapy with Toll-like receptor (TLR) agonists to enhance parasite-specific immune responses. We have previously reported that vaccination of C57BL/6 mice with live L. major plus the TLR9 agonist CpG DNA prevents lesion d...

Visceral leishmaniasis (VL) is a fatal disease of the internal organs caused by the eukaryotic parasite Leishmania. Control of VL would best be achieved through vaccination. However, this has proven to be difficult partly because the correlates of protective immunity are not fully understood. In contrast, protective immunity against nonfatal cutaneous leishmaniasis (CL) is well defined and medi...

Title of Document: THE DEVELOPMENT AND CHARACTERIZATION OF TRANSGENIC LEISHMANIA MAJOR EXPRESSING MURINE CD40L. Ann Elizabeth Field, Ph.D., 2007 Directed By: David Mosser, Professor, Cell Biology and Molecular Genetics Leishmanization is the inoculation of live Leishmania into the host to vaccinate against subsequent infections. This approach has been largely discontinued due to safety concerns...

background : historically, leishmanization is the most effective protective measure against cutaneous leishmaniasis (cl), cl lesion induced by leishmanization sometimes takes a long time to heal. ma­nipulation of leishmanization inoculums needed to induce a mild and acceptable cl lesion. the aim of this study was to explore if liposomal form of cpg odn (cytosin phosphate guanin oligodeoxynu­cle...

Numerous experimental vaccines have been developed to protect against the cutaneous and visceral forms of leishmaniasis caused by infection with the obligate intracellular protozoan Leishmania, but a human vaccine still does not exist. Remarkably, the efficacy of anti-Leishmania vaccines has never been fully evaluated under experimental conditions following natural vector transmission by infect...

Background and Objectives Leishmania are intracellular flagellate protozoan parasites cause a wide spectrum of clinical manifestations in human. The immunological basis for resistance against leishmaniasis depends on Thl responses in the course of performance of cytokines like IL-12. In this study, a transgenic Leishmania coding human IL-12 was produced that can be used in Leishmanization. Ma...