This article comprises detail information about Lasparaginase, encompassing topic such as various sources of Lasparaginase, mechanism and properties of L-asparaginase. Also describe the production, cultivation and purification of Lasparaginase along with information about the application of Lasparaginase. L-asparaginase catalyzes the conversion reaction to convert asparagine to aspartic acid an...

This article comprises detail information about Lasparaginase, encompassing topic such as various sources of Lasparaginase, mechanism and properties of L-asparaginase. Also describe the production, cultivation and purification of Lasparaginase along with information about the application of Lasparaginase. L-asparaginase catalyzes the conversion reaction to convert asparagine to aspartic acid an...

Susmita Shukla and S.K. Mandal Department of Biochemical Engineering and Food Technology, Harcourt Butler Technological Institute, Kanpur-208002, India. E-mail: [email protected] ABSTRACT: L-asparaginase has been used as anti-tumor agent for the treatment of acute lymphoblastic leukemia and food processing aid to reduce the formation of cancer causing acrylamide. Extracellular Lasp...

The advances in low-grade lymphoma & T-cell lymphoma from the 2008 ASH meeting were presented. These included therapeutic regimens for low grade lymphoma, frontline bendamustine plus rituximab data, radioimmunotherapy consolidation in advanced disease, idiotype vaccine, and other novel therapeutic agents such as next generation anti-CD20 GA101, syk inhibitor Fostamatinib in treatment of low-gra...

L-asparaginase is an anti-neoplastic agent used in the chemotherapy of lymphoblastic leukaemia. The present work deals with production of extra-cellular Lasparaginase from marine actinomycetes, using submerged fermentation. Marine actinomycete Streptomyces associated with marine spongeCallyspongia diffusa was isolated using specific ISP medium. Sponge-associated Streptomyces was character...

It is, howvver, difficult to explain on this basis how a patienmay resp6nd again once resistance has occurred (Figs. 1-4). For these reasons we believe that asparaginase should be used in combination with other drugs in the treatment of acute leukaemia. Although when used alone it does not produce complete remission in acute myeloid leukaemia, it still may have a part to play when used in combi...

The biosensor for monitoring asparagine levels in Fruit juices was developed in present research work. Lasparaginase (biocomponent) has been extracted from Withania somnifera (L) Dunal, and immobilized into TEOS hydrosol gel-chitosan matrix. Kinetic characterization of both native and immobilized enzyme was compared. Response time studies had been carried out by Phenol Red indicator coimmobiliz...

L-asparaginase (L-asparagine amido hydrolase, E.C.3.5.1.1) is an extracellular enzyme having potential therapeutic applications. In the present study, production and partial purification of L-asparaginase fromPseudomonas aeruginosausing solid state fermentation was carried out. It is inferred thatthe bacterial growth was observed in cetrimide agar medium after 48 hours of incubation. The isolat...

Enzyme L-asparaginase (L-asparagines amidohydrolase EC 3.5.1.1) has the physiological function of hydrolyzing amide group of the side chain in Lasparagine to produce L-aspartate and ammonia. This spectacular property of the enzyme is utilized in chemotherapeutic treatment of certain kinds of lymphoblastic malignancies, mainly in acute lymphoblastic leukaemia (ALL) and lympho-sarcoma for nearly ...