lamotrigine has been used widely in the treatment of partial and secondary generalized seizures. in this study use of lamotrigine as monotherapy for the newly diagnosed primary generalized tonic–clonic seizure has been investigated and compared with carbamazepine. after dose escalation (3 weeks for carbamazepine and 6 weeks for lamotrigin), patients were followed every 4 weeks for the first 16 ...

epilepsy is a common neurologic disorder affecting approximately 1% of the population. the prevalence of active epilepsy in kerman,iran is 7.87/1000 individuals. the past decade has brought many advances to the treatment of epilepsy, including many new pharmacological agents. lamotrigine is one of the new antiepileptic drugs. lamotrigine has many side effects; the most important of which are al...

Lamotrigine is an antiepileptic drug used as a treatment for partial and generalised seizures as well as for bipolar disorder type I. Till date, very few cases of lamotrigine overdose have been reported. The spectra of clinical effects of lamotrigine in acute overdose are not well established. In severe cases of poisoning, serious effects such as coma, respiratory depression, recurrent seizures...

Background: Central post-stroke pain (CPSP) is a distressing pain syndrome, sometimes become refractory to the conventional pain managements. Anticonvulsants have been used to alleviate different central pains. Lamotrigine is a novel anticonvulsant and its proper dosage and its efficacy have not been well studied yet. The aim of this study was to evaluate the effect of 100 mg lamotrigine on ref...

Epilepsy is a common neurologic disorder affecting approximately 1% of the population. The prevalence of active epilepsy in Kerman,Iran is 7.87/1000 individuals. The past decade has brought many advances to the treatment of epilepsy, including many new pharmacological agents. Lamotrigine is one of the new antiepileptic drugs. Lamotrigine has many side effects; the most important of which are al...

lamotrigine is an antiepileptic drug used as a treatment for partial and generalised seizures as well as for bipolar disorder type i. till date, very few cases of lamotrigine overdose have been reported. the spectra of clinical effects of lamotrigine in acute overdose are not well established. in severe cases of poisoning, serious effects such as coma, respiratory depression, recurrent seizures...

AIM To estimate the effect size of concomitant antiepileptic therapy on the concentrations of lamotrigine, a drug often prescribed in combination with other antiepileptic drugs (AED), which can act as enzyme inducers or inhibitors. METHODS A total of 304 patients with epilepsy, aged 18-70 years, were divided into a lamotrigine monotherapy group and groups receiving lamotrigine with AEDs that ...

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INTRODUCTION Lamotrigine is widely used for mood disorders including bipolar disorder and major depression, but its therapeutic levels have yet to be determined. This study was conducted to investigate the hypothesis that lamotrigine may have a therapeutic window for mood disorders. METHODS 25 patients with mood disorders received lamotrigine for more than one year during which time plasma la...

The purpose of this study was to estimate the effect sizes of drug interactions on plasma olanzapine concentrations while adjusting for potentially confounding factors such as smoking. The estimation was performed by using a mixed model, data from a series of previously published studies of lamotrigine, oxcarbazepine, topiramate, and mirtazapine, and unpublished data from patients under clinica...