Laminitis (also known as Founder) is one of the most devastating and feared diseases from which horses can suffer . It is caused by extremely painful inflammation in the sensitive laminae in the hoof, and can result in death or permanent lameness . Recent research has shed new light on the causes of laminitis . Most importantly, we now know what owners can do to minimize their own horse’s risk ...

Vasodilation precedes the development of carbohydrate overload laminitis. Circulating laminitis trigger factors activate lamellar enzymes, which lyse the attachments between the distal phalanx and the inner hoof wall. The clinical signs of laminitis occur when the lamellar architecture disintegrates. The amount of pain correlates with the extent of lamellar pathology. A substance produced by St...

REASONS FOR PERFORMING STUDY A previous preliminary study demonstrated the potential of distal limb cryotherapy (DLC) for preventing laminitis. Clinically, DLC must be effective for periods longer than 48 h and the preventive effect must extend beyond its discontinuation. OBJECTIVES To evaluate the effect of DLC, applied during the developmental phase of induced laminitis, on the severity of ...

significantly fewer publications have addressed the association between laminitis and pathological conditions of the horse’s endocrinological system (Schott 2002). This difference in research emphasis can be partly explained by the availability of useful and predictable models for the purposes of studying experimentally-induced laminitis that involve administration of either starch or a soluble...

Laminitis is a major disease of horses because of the associated pain and debilitating nature that make it a life-threatening condition. A complete understanding of laminitis and its complex pathophysiologic processes remains elusive despite substantial efforts and recent advances by many scientists over the last few decades. For this reason, preventative and therapeutic management strategies r...

Liposomes are phospholipid nanoparticles used for targeted drug delivery. This study aimed to determine whether intravenous liposomes accumulate in lamellar tissue during laminitis development in horses so as to assess their potential for targeted lamellar drug delivery. Polyethylene-glycol (PEG) coated liposomes were prepared according to the film hydration method and labelled using (99m)Tc-he...

Data from 107 cases of pasture-associated laminitis were obtained from first opinion practices to study factors associated with severity, survival and return to ridden exercise. There were 43 mares and 64 geldings, with a median age of 11 years. Of the 107 animals, 33 were small ponies, 45 were large ponies/cobs, 17 were small horses and 12 were large horses. Ninetyseven animals were categorise...

Laminitis is one of the most common and frustrating clinical presentations in equine practice. While the principles of treatment for laminitis have not changed for several decades, there have been some important paradigm shifts in our understanding of laminitis. Most importantly, it is essential to consider laminitis as a clinical sign of disease and not as a disease in its own right. Once this...

Although much has been written about laminitis in the context of its association with inflammatory processes, recognition is growing that most cases of laminitis examined by veterinarians in private practice are those associated with pasture grazing, obesity, and insulin resistance (IR). The term 'endocrinopathic laminitis' has been adopted to classify the instances of laminitis in which the or...

Laminitis is the second most common cause of death from disease in horses and causes great suffering animal economic emotional losses for people involved. Several therapeutic modalities are used treatment this disease, but their results not consistently described literature. In scenario, deep digital flexor (DDF) tenotomy a modality that can be chronic laminitis, releasing traction force DDF te...