purpose:  to report a case of lymphangioma in the lacrimal gland. case report: a 6-year old boy with acute proptosis and inferonasal displacement of the globe was referred.  in ct-scan revealed a heterogenous enlargement of the lacrimal gland. steroid therapy did not lead to a significant improvement. during surgical exploration, a dark black liquid was extracted from the site of the lacrimal g...

Background: Amiodarone is a drug that is used for treatment of cardiac arrhythmia after cardiac ischemia. This drug as b blocker decreases arrhythmia rate but it has many side effects on different tissues. Since there are rare reports about changes of lacrimal glands, this research has been carried out to study the morphological and ultrastructural changes of lacrimal gland cells after amiodaro...

BACKGROUND The study of human lacrimal gland biology and development is limited. Lacrimal gland tissue is damaged or poorly functional in a number of disease states including dry eye disease. Development of cell based therapies for lacrimal gland diseases requires a better understanding of the gene expression and signaling pathways in lacrimal gland. Differential gene expression analysis betwee...

background: the therapeutic administration of 131i for thyroid remnant ablation and for metastases comes up with some adverse effects. this study was conducted to investigate whether single high dose radioiodine therapy affects lacrimal gland functions or not. materials and methods: seventy-eight eyes of 39 patients, who were diagnosed as differentiated thyroid carcinoma, were objectively teste...

PURPOSE The purpose of the present study was to investigate the roles of caspase 1 and extracellular signal-regulated kinase (ERK) in inflammation-induced inhibition of lacrimal gland secretion. METHODS Lacrimal gland inflammation was induced by injection of lipopolysaccharide (LPS; to study the role of caspase 1) or IL-1beta (to study the role of ERK). Lacrimal gland protein secretion was me...

BACKGROUND Decreased lacrimal gland output may cause dry eye syndrome. Using a rat model, we examined the feasibility of transplanting lacrimal gland cells from newborns. OBJECTIVES To restore lacrimal gland function in eyes with compromised tear production. METHODS A model of dry eye in adult rats was developed by unilateral surgical removal of the main lacrimal gland. Tear secretion in bo...

The lacrimal gland has a multifaceted role in maintaining a homeostatic microenvironment for a healthy ocular surface via tear secretion. Dry-eye disease, which is caused by lacrimal gland dysfunction, is one of the most prevalent eye diseases that cause corneal epithelial damage and results in significant loss of vision and a reduction in the quality of life. Here we demonstrate orthotopic tra...

PURPOSE Differential display analysis was used to look for gender differences in lacrimal gland gene expression. The expression of a female-specific mouse lacrimal gland mRNA that encoded pancreatic lipase-related protein 1 (PLRP1) was identified and characterized. METHODS Differential display analysis of the exorbital lacrimal glands of male and female Swiss Webster mice detected a potential...

BACKGROUND:. The lacrimal gland is un-capsulated, multilobulated secretory gland situated in the lacrimal gland fossa, behind the supratemporal orbital rim. Tumor and Lesion of the lacrimal gland contain 5 to 18 % of all orbital mass. Aims and objectives: To study the incidence and prevalence of tumor of lacrimal gland. To study the clinical pattern with regard to age, incidence, gender distrib...

background: amiodarone is a drug that is used for treatment of cardiac arrhythmia after cardiac ischemia. this drug as b blocker decreases arrhythmia rate but it has many side effects on different tissues. since there are rare reports about changes of lacrimal glands, this research has been carried out to study the morphological and ultrastructural changes of lacrimal gland cells after amiodaro...