نتایج جستجو برای: LTB

تعداد نتایج: 643  

Journal: :The Biochemical journal 1999
K Masuda T Yokomizo T Izumi T Shimizu

The cDNA for leukotriene B(4) (LTB(4)) receptor (BLT) was cloned from a guinea-pig leucocyte cDNA library. The cloned receptor cDNA encodes 348 amino acid residues and shares 73% identity with the amino acid sequence of human BLT. Northern blot analysis showed the highest expression of the receptor mRNA in leucocytes, followed by lung and spleen. The membrane fractions of HEK-293 and Cos-7 cell...

2016
Lin Liu Yongping Ma Huicong Zhou Mingjun Wu

The nontoxic heat-labile toxin (LT) B subunit (LTB) was used as mucosal adjuvant experimentally. However, the mechanism of LTB adjuvant was still unclear. The LTB and enterovirus 71 (EV71) VP1 subunit (EVP1) were constructed in pET32 and expressed in E. coli BL21, respectively. The immunogenicity of purified EVP1 and the adjuvanticity of LTB were evaluated via intranasal immunization EVP1 plus ...

Journal: :Research in veterinary science 2012
Xuelin Wang Juan Liu Xiuping Wu Lu Yu Haiying Chen Heng Guo Maolin Zhang Huiping Li Xue Liu Shumin Sun Lijing Zhao Xinyue Zhang Lifang Gao Mingyuan Liu

To investigate effective new rabies vaccines, a fusion protein consisting of the rabies virus (RV) glycoprotein and the heat-labile enterotoxin B subunit of Escherichia coli (LTB) was successfully constructed and delivered in a live attenuated Salmonella strain LH430. Mice were immunised with LH430 carrying pVAX1-G, pVAX1-G-LTB or pVAX1-ori-G-LTB. The antibody titres of mice immunised with oral...

Journal: :American journal of physiology. Heart and circulatory physiology 2004
Magnus Bäck Hong Qiu Jesper Z Haeggström Kiyoto Sakata

Leukotriene B(4) (LTB(4)) is a potent leukocyte chemoattractant recently implicated in the pathogenesis of atherosclerosis. The aim of this study was to assess the effects of LTB(4) on isolated aortic preparations. Rings of guinea pig aorta were challenged with LTB(4) for recording mechanical responses and measurements of mediator release, and LTB(4) receptor (BLT(1)) expression was assessed by...

Journal: :The Journal of Experimental Medicine 2000
Andrew M. Tager Jennifer H. Dufour Katayoon Goodarzi Scott D. Bercury Ulrich H. von Andrian Andrew D. Luster

Leukotriene B(4) (LTB(4)) is a potent chemoattractant active on multiple leukocytes, including neutrophils, macrophages, and eosinophils, and is implicated in the pathogenesis of a variety of inflammatory processes. A seven transmembrane-spanning, G protein-coupled receptor, called BLTR (LTB(4) receptor), has recently been identified as an LTB(4) receptor. To determine if BLTR is the sole recep...

Journal: :The Journal of pharmacology and experimental therapeutics 2001
F W Birke C J Meade R Anderskewitz G A Speck H M Jennewein

BIIL 284 is a new LTB(4) receptor antagonist. It is a prodrug and has negligible binding to the LTB(4) receptor. However, ubiquitous esterases metabolize BIIL 284 to the active metabolites BIIL 260 and BIIL 315, the glucuronidated form of BIIL 260. Both metabolites have high affinity to the LTB(4) receptor on isolated human neutrophil cell membranes with K(i) values of 1.7 and 1.9 nM, respectiv...

Journal: :مجله دانشگاه علوم پزشکی شهرکرد 0
علی میری ali miri biology dept., imam hossein university, tehran, iran; 2human genetic research center, baqiyatallah university of medical sciences, tehran, iran;مرکز تحقیقات زیست شناسی، دانشگاه جامع امام حسین(ع)، تهران، ایران جعفر سلیمیان jafar salimian chemical injuries research center, baqiyatallah university of medical sciences, tehran, i.r. iran. tel: 00982182482481,تهران- دانشگاه علوم پزشکی بقیه الله(عج- مرکز تحقیقات آسیب های شیمیایی- تلفن: 82482491-021، احسان رضایی ehsan rezai 1biology dept., imam hossein university, tehran, iran;4chemical injuries research center, baqiyatallah university of medical sciences, tehran, iran;4chemical injuries research center, baqiyatallah university of medical sciences, tehran, iran; 4chemical injuries research center, baqiyatallah university of medical sciences, tehran, iran;1مرکز تحقیقات زیست شناسی، دانشگاه جامع امام حسین(ع)، تهران، ایران4 مرکز تحقیقات بیوتکنولوژی کاربردی، دانشگاه علوم پزشکی بقیه الله (عج)، تهران، ایران غلامرضا اولاد gholamreza olad chemical injuries research center, baqiyatallah university of medical sciences, tehran, iran;مرکز تحقیقات بیوتکنولوژی کاربردی، دانشگاه علوم پزشکی بقیه الله (عج)، تهران، ایران مجتبی سعادتی mojtaba sadati biology dept., imam hossein university, tehran, iranمرکز تحقیقات زیست شناسی، دانشگاه جامع امام حسین(ع)، تهران، ایران محمد علی عارف پور ترابی mohammad ali arefpour-tehrani biology dept., imam hossein university, tehran, iranمرکز تحقیقات زیست شناسی، دانشگاه جامع امام حسین(ع)، تهران، ایران فرید عزیزی جلیلیان

background and aims: among the bacterial agents, the most common cause of diarrheal disease is entrotoxigenic escherichia coli. letal toxin b (ltb) subunit of lt toxin could induce six-month immunity. clostridium botulinum causes botulism disease. bont/a-hc toxin subunit could induce two years immunity against this disease. it seems that the immunogenicity potency of these two subunits may infl...

Journal: :The Journal of infectious diseases 2004
Louis Flamand Pierre Borgeat Richard Lalonde Jean Gosselin

BACKGROUND CD8(+) T cells can control human immunodeficiency virus (HIV) through the lysis of infected cells and the release of soluble mediators, such as macrophage inflammatory protein (MIP)-1 beta, which prevent entry of HIV and/or inhibit HIV replication. Because neutrophils represent a major source of alpha-defensins and, to a lesser extent, MIP-1 beta, we determined whether leukotriene B(...

Journal: :Journal of immunology 2010
Mei Chen Bing K Lam Andrew D Luster Simona Zarini Robert C Murphy Angela M Bair Roy J Soberman David M Lee

Mechanisms by which mesenchymal-derived tissue lineages participate in amplifying and perpetuating synovial inflammation in arthritis have been relatively underinvestigated and are therefore poorly understood. Elucidating these processes is likely to provide new insights into the pathogenesis of multiple diseases. Leukotriene B(4) (LTB(4)) is a potent proinflammatory lipid mediator that initiat...

Journal: :iranian journal of microbiology 0
j salimian department of immunology, faculty of medical sciences, tarbiat modares university. ah salmanian department of plant biotechnology, national institute of genetic engineering and biotechnology (nigeb), tehran, iran. r khalesi department of immunology, faculty of medical sciences, tarbiat modares university. m mohseni department of immunology, faculty of medical sciences, tarbiat modares university. sm moazzeni department of immunology, faculty of medical sciences, tarbiat modares university.

objectives: enterotoxigenic escherichia coli (etec) is one of the most common agents of diarrhea among other bacterial agents. designing and producing vaccine against these bacteria is one of the major purposes of world health organization (who). due to presence of diverse clones of etec strains in the world, the use of global vaccines for etec infection is controversial. b subunit of heat labi...

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