a quantitative structure–activity relationship (qsar) study is suggested for the prediction of biological activity (pic 50 ) of 3, 4-dihydropyrido [3 ,2-d] pyrimidone derivatives as p38 inhibitors. modeling of the biological activities of compounds of interest as a function of molecular structures was established by means of principal component analysis (pca) and least square support vector mac...

a method based on electrical capacitance tomography (ect) and an improved least squares support vector machine (ls-svm) is proposed for void fraction measurement of oil-gas two-phase flow. in the modeling stage, to solve the two problems in ls-svm, pruning skills are employed to make ls-svm sparse and robust; then the real-coded genetic algorithm is introduced to solve the difficult problem of ...

A method based on Electrical Capacitance Tomography (ECT) and an improved Least Squares Support Vector Machine (LS-SVM) is proposed for void fraction measurement of oil-gas two-phase flow. In the modeling stage, to solve the two problems in LS-SVM, pruning skills are employed to make LS-SVM sparse and robust; then the Real-Coded Genetic Algorithm is introduced to solve the difficult problem...

a simple and rapid method for the determination of 137ba isotope abundances in water samples by inductively coupled plasma-optical emission spectrometry (icp-oes) coupled with least-squares support vector machine regression (ls-svm) is reported. by evaluation of emission lines of barium, it was found that the emission line at 493.408 nm provides the best results for the determination of 137ba a...

This paper proposes the least-squares support vector machine (LS-SVM) as an intelligent method applied on absorption spectra for the simultaneous determination of paracetamol (PCT), caffeine (CAF) and ibuprofen (IB) in Novafen. The signal to noise ratio (S/N) increased. Also, In the LS - SVM model, Kernel parameter (σ2) and capacity factor (C) were optimized. Excellent prediction was shown usin...

Neural networks play an important role in system modelling. This is especially true if model building is mainly based on observed data. Among neural models the Support Vector Machine (SVM) solutions are attracting increasing attention, mostly because they automatically answer certain crucial questions involved by neural network construction. They derive an ‘optimal’ network structure and answer...

The aim of this study is to develop the Bayesian Least Squares Support Vector Machine (LS-SVM) classifiers, for preoperatively predicting the malignancy of ovarian tumors. We describe how to perform parameter estimation, input variable selection for LS-SVM within the evidence framework. The issue of computing the posterior class probability for risk minimization decision making is addressed. Th...

in this paper, we present a new brain tissue segmentation method based on a hybrid hierarchical approach that combines a brain atlas as a priori information and a least-square support vector machine (ls-svm). the method consists of three steps. in the first two steps, the skull is removed and cerebrospinal fluid (csf) is extracted. these two steps are performed using the fast toolbox (fmrib's a...

Loan default evaluation and discrimination is a complicated issue because of its nonlinearity and uncertainty. Least square support vector machine (LS-SVM) has been successfully employed to solve regression and time series problem. This paper proposes a novel PSO-LS-SVM model based on the improved PSO algorithm to optimize parameters of LS-SVM, which is a new improved form by synthesizing the e...