نتایج جستجو برای: LPS outer core

تعداد نتایج: 299172  

Journal: :Frontiers in microbiology 2016
Susana Merino Juan M. Tomás

Initial hydridization tests using Aeromonas salmonicida typical and atypical strains showed the possibility of different lipopolysaccharide (LPS) outer cores among these strains. By chemical structural analysis, LPS-core SDS-PAGE gel migration, and functional and comparative genomics we demonstrated that typical A. salmonicida (subsp. salmonicida) strains and atypical subsp. masoucida and proba...

Journal: :Glycobiology 2013
Marina Harper Frank St Michael Evgeny Vinogradov Marietta John Jason A Steen Lieke van Dorsten John D Boyce Ben Adler Andrew D Cox

Pasteurella multocida strains are classified into 16 Heddleston serovars on the basis of the lipopolysaccharide (LPS) antigens expressed on the surface of the bacteria. The LPS structure and the corresponding LPS outer core biosynthesis loci of strains belonging to serovars 1, 2, 3, 5, 9 and 14 have been characterized, revealing a clear structural basis for serovar classification. However, seve...

Journal: :Journal of bacteriology 2013
Marina Harper Frank St Michael Marietta John Evgeny Vinogradov Jennifer A Steen Lieke van Dorsten Jason A Steen Conny Turni Patrick J Blackall Ben Adler Andrew D Cox John D Boyce

Pasteurella multocida is a Gram-negative multispecies pathogen and the causative agent of fowl cholera, a serious disease of poultry which can present in both acute and chronic forms. The major outer membrane component lipopolysaccharide (LPS) is both an important virulence factor and a major immunogen. Our previous studies determined the LPS structures expressed by different P. multocida strai...

Journal: :Journal of bacteriology 2009
Nikolay A Paramonov Joseph Aduse-Opoku Ahmed Hashim Minnie Rangarajan Michael A Curtis

Porphyromonas gingivalis synthesizes two lipopolysaccharides (LPSs), O-LPS and A-LPS. Here, we elucidate the structure of the core oligosaccharide (OS) of O-LPS from two mutants of P. gingivalis W50, Delta PG1051 (WaaL, O-antigen ligase) and Delta PG1142 (O-antigen polymerase), which synthesize R-type LPS (core devoid of O antigen) and SR-type LPS (core plus one repeating unit of O antigen), re...

Journal: :Infection and immunity 2003
D Monreal M J Grilló D González C M Marín M J De Miguel I López-Goñi J M Blasco A Cloeckaert I Moriyón

Brucella abortus rough lipopolysaccharide (LPS) mutants were obtained by transposon insertion into two wbk genes (wbkA [putative glycosyltransferase; formerly rfbU] and per [perosamine synthetase]), into manB (pmm [phosphomannomutase; formerly rfbK]), and into an unassigned gene. Consistent with gene-predicted roles, electrophoretic analysis, 2-keto-3-manno-D-octulosonate measurements, and immu...

Journal: :Glycobiology 2014
Marina Harper Frank St Michael Marietta John Jason Steen Lieke van Dorsten Henrietta Parnas Evgeny Vinogradov Ben Adler Andrew D Cox John D Boyce

Pasteurella multocida is a Gram-negative bacterial pathogen classified into 16 serovars based on lipopolysaccharide (LPS) antigens. Previously, we have characterized the LPS outer core biosynthesis loci L1, L2, L3, L5 and L7, and have elucidated the full range of LPS structures associated with each. In this study, we have determined the LPS structures produced by the type strains representing t...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه تربیت مدرس - دانشکده علوم پزشکی 1392

بروسلا یک انگل داخل سلولی اختیاری که قابلیت بقا داخل سلولهای فاگوسیتیک میزبان را دارا می باشد. پاکسازی بروسلا ها با فعال شدن ماکروفاژها به واسطه ایمنی سلولی وابسته به لمفوسیت های نوع th-1 انجام می شود. lps بروسلا مهمترین فاکتور بیماریزایی آن محسوب می شود و ساختار ops از مولکول lps بیشترین نقش را در بیماریزایی و بقای داخل سلولی باکتری دارد. برای ایجاد ایمنی علیه lps بروسلاهای صاف، بخش core نیز ب...

Journal: :Journal of bacteriology 2005
Koji Hiratsuka Susan M Logan J Wayne Conlan Vandana Chandan Annie Aubry Natalia Smirnova Heather Ulrichsen Kenneth H N Chan Douglas W Griffith Blair A Harrison Jianjun Li Eleonora Altman

We have identified a Helicobacter pylori d-glycero-d-manno-heptosyltransferase gene, HP0479, which is involved in the biosynthesis of the outer core region of H. pylori lipopolysaccharide (LPS). Insertional inactivation of HP0479 resulted in formation of a truncated LPS molecule lacking an alpha-1,6-glucan-, dd-heptose-containing outer core region and O-chain polysaccharide. Detailed structural...

Journal: :Infection and immunity 1997
S K Gupta S Masinick M Garrett L D Hazlett

The aim of this study was to test whether galectin-3 is present in human corneal epithelium and whether lipopolysaccharide (LPS) purified from Pseudomonas aeruginosa ATCC 19660 binds to this animal lectin and/or to another human corneal epithelial protein(s) (HCEP) and to confirm which component of LPS (inner or outer core or lipid A) is important in bacterial binding by using the eye in organ ...

Pasteurella multocida isa gram-negative bacterial pathogen that is causative agent of a wide range of diseases in many animal species and humans. Lipopolysaccharides (LPS) are an important virulence factor, minor changes to structure of which can exert dramatic effects on pathogenicity of P. multocida in its host. LPS can be used for the identification and classification of strains with somatic...

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