Purpose To introduce SHERPA-LEAP, a model for the consortial development, population and support of eprints repositories. Design/methodology/approach The organisational and technical structures of the consortium are described, including a brief summary of central and local resource responsibilities. Some positive and negative aspects of a consortial approach to institutional repository developm...

In a graph G, the first and second degrees of a vertex v is equal to thenumber of their first and second neighbors and are denoted by d(v/G) andd 2 (v/G), respectively. The first, second and third leap Zagreb indices are thesum of squares of second degrees of vertices of G, the sum of products of second degrees of pairs of adjacent vertices in G and the sum of products of firs...

Background: Liver-expressed antimicrobial peptide-2 (LEAP-2) is an important component of innate immune system in teleosts. In order to understand isoform-specific involvement and regulation of LEAP-2 genes in mud loach (Misgurnus mizolepis, Cypriniformes), a commercially important food fish, this study was aimed to characterize gene structure and expression characteristics of two paralog LEAP-...

We describe the core of a new strongly-typed functional programming language called LEAP, a \Language with Eval And Polymorphism." Pure LEAP is an extension of the !-order polymorphic -calculus (F ! ) by global de nitions that allows the representation of programs and the de nition of versions of reify, reflect, and eval for all of F ! . Pure LEAP is therefore highly re exive and strongly typed...

By explicitly representing well-stirred chemical reaction systems with independent, unit Poisson processes we develop a new adaptive tau-leaping procedure. The procedure developed is novel in that we enforce any leap condition via a post-leap check as opposed to performing a pre-leap tau selection. Further, we perform the post-leap check in such a way that the statistics of the sample paths gen...

A new algorithm, "HiER-leap" (hierarchical exact reaction-leaping), is derived which improves on the computational properties of the ER-leap algorithm for exact accelerated simulation of stochastic chemical kinetics. Unlike ER-leap, HiER-leap utilizes a hierarchical or divide-and-conquer organization of reaction channels into tightly coupled "blocks" and is thereby able to speed up systems with...