BACKGROUND African Americans have a disproportionate burden of hypertension and comorbid disease. Pharmacogenetic markers of blood pressure response have yet to be defined clearly. This study explores the association between G-protein-coupled receptor kinase type 4 (GRK4) variants and blood pressure response to metoprolol among African Americans with early hypertensive nephrosclerosis. METHOD...

Background The changes in corneal biomechanical properties after LASIK remain an unknown but important topic for surgical design and prognostic evaluation. This study aims to observe the postoperative corneal biomechanical properties one month after LASIK with amount of corneal cutting (ACC) greater than 50% of the central corneal thickness (CCT). Methods FS-LASIK was performed in 10 left rab...

We use new data on the location and background of entrants into the US tyre industry to analyse why the industry became so regionally concentrated around Akron, Ohio, a small city with no compelling advantages for tyre production. We analyse where the Ohio entrants originated and conduct various analyses of how proximity to other tyre firms affected the longevity of tyre producers. We also exam...

When effort is multi-dimensional, firms will optimally “balance” the provision of incentives. Setting high-powered incentives along one dimension raises the returns to providing high-powered incentives along other dimensions which compete for the worker’s effort and/or attention (Holmstrom and Milgrom, 1991). We test for this effect in the context of for-profit pharmaceutical laboratories using...

This version of September 3, 2006. German chemical manufacturing industry is marked by two major structural changes during 1992–2004. Firstly, number of firms was ranging extensively: from 676 to 901, while only 96 firms represented balanced panel. Secondly, size of the firm dropped considerably—by 88%. This paper is intended to shed light on both phenomena. Based on reliable census data analys...

This paper examines how an incumbent’s patent protection acts as an implicit subsidy toward non-infringing substitutes. I analyze whether classes of pharmaceuticals whose first entrant has a longer period of market exclusivity (time between approval and generic entry) see more subsequent entry. Instrumenting for exclusivity using plausibly exogenous delays in the development process, I find tha...

This paper describes three prototypical systems of therapeutic reference pricing (RP) for pharmaceuticals -Germany, the Netherlands, and New Zealand -and examines their effects on the availability of new drugs; manufacturer prices, reimbursement levels, and out-of-pocket surcharges to patients; and market shares of originator and generic products. The results differ across countries in predicta...

This paper investigates interactions between exporting and productivity at the firm level, using a panel of firms in the UK chemical industry. This is both highly technology intensive and the UK’s largest exporting sector. We find exporters are more productive than non-exporters, but are also on average smaller. This superior productivity performance among exporters appears to be caused by both...

This version of January 26, 2007. German chemical manufacturing industry experienced a major downsizing during 1992–2004. On the average, size of the firm almost halved. Using modern frontier efficiency analysis, this paper investigates technical and scale efficiency of firms. Based on reliable census data, analysis suggests that firms were not primarily concerned with improving technical effic...