according to global statistics, over 80,000 deaths occur by suicide annually. up to 90% of complete suicides are based on psychiatric disorders specifically major depressive disorder (mdd) and bipolar disorder. furthermore high levels of inflammation have been indicated in suicidal patients in both central nervous system and the peripheral blood. two biological mechanisms that play a key role i...

According to global statistics, over 80,000 deaths occur by suicide annually. Up to 90% of complete suicides are based on psychiatric disorders specifically major depressive disorder (MDD) and bipolar disorder. Furthermore high levels of inflammation have been indicated in suicidal patients in both central nervous system and the peripheral blood. Two biological mechanisms that play a key role i...

The opportunistic pathogen Pseudomonas aeruginosa can utilize a variety of carbon sources and produces many secondary metabolites to help survive harsh environments. P. aeruginosa is part of a small group of bacteria that use the kynurenine pathway to catabolize tryptophan. Through the kynurenine pathway, tryptophan is broken down into anthranilate, which is further degraded into tricarboxylic ...

Background The kynurenine pathway of tryptophan oxidation is associated with central nervous system (CNS) inflammatory pathways. Inhibition of this pathway ameliorates CNS inflammation in rodent models of the late (meningoencephalitic) stage of human African trypanosomiasis (HAT). In this study, we evaluate whether the kynurenine pathway is activated in clinical HAT and associated with CNS infl...

Subcutaneous administration of L-thyroxine (75 pg/lOO g of body weight per day) to rats for 10 to 14 days caused a decrease in the activity of kynurenine 3-hydroxylase to about 50% of the control value. Enzymic properties of kynurenine 3-hydroxylase of mitochondrial outer membrane preparations isolated from normal and L-thyroxine-treated rats were almost identical, suggesting that L-thyroxine a...

The cells of the anterior region of the larval fatbody of Drosophila melanogaster accumulate kynurenine at the end of the third larval instar, whereas the cells of the posterior region are involved in pteridine metabolism. Through a series of transplantation experiments it has been demonstrated that the anterior fat cells synthesize kynurenine. The mutant vermilion lacks kynurenine, and the ant...

Near the time of pupation, autofluorescent kynurenine globules appear in the cells in the anterior region of the fatbody of Drosophila melanogaster. It has been reported previously that kynurenine synthesis may be induced in an additional group of fat cells by feeding the precursor tryptophan to Drosophila larvae, and that this induction of kynurenine production viewed within the fat cells is c...

Subcutaneous administration of L-thyroxine (75 pg/lOO g of body weight per day) to rats for 10 to 14 days caused a decrease in the activity of kynurenine 3-hydroxylase to about 50% of the control value. Enzymic properties of kynurenine 3-hydroxylase of mitochondrial outer membrane preparations isolated from normal and L-thyroxine-treated rats were almost identical, suggesting that L-thyroxine a...

Alterations in the cellular synthesis of kynurenine in the larval fatbody of Drosophila melanogaster may be obtained by feeding the precursor tryptophan or by changing the genotype. In the wild type Ore-R strain, autofluorescent kynurenine globules normally occur in the cells in the anterior regions of the fatbody designated as regions 1, 2, and 3. When tryptophan is included in the larval diet...