the assessment of de-desertification alternatives can be effective in controlling the reclamation of disturbed landand avoiding destruction of areas at risk. until now, there has been no method to consider different criteria andalternatives, or to present the optimum alternatives based on systematic structures and experts’ perspectives.desertification is a complex process resulting from various...

Mitochondrial dysfunction is a hallmark of beta-amyloid (Abeta)-induced neuronal toxicity in Alzheimer's disease (AD). Here, we demonstrate that Abeta-binding alcohol dehydrogenase (ABAD) is a direct molecular link from Abeta to mitochondrial toxicity. Abeta interacts with ABAD in the mitochondria of AD patients and transgenic mice. The crystal structure of Abeta-bound ABAD shows substantial de...

Amyloid β peptide binding alcohol dehydrogenase (ABAD) decoy peptide (DP) can competitively antagonize binding of amyloid β peptide to ABAD and inhibit the cytotoxic effects of amyloid β peptide. Based on peptide aptamers, the present study inserted ABAD-DP into the disulfide bond of human thioredoxin (TRX) using molecular cloning technique to construct a fusion gene that can express the TRX1-A...

Amyloid beta (Aβ) binding alcohol dehydrogenase (ABAD) is a cellular cofactor for promoting (Aβ)-mediated mitochondrial and neuronal dysfunction, and cognitive decline in transgenic Alzheimer's disease (AD) mouse models. Targeting mitochondrial ABAD may represent a novel therapeutic strategy against AD. Here, we report the biological activity of small molecule ABAD inhibitors. Using in vitro su...

introduction two main principal aspects for the genesis of porphyry copper deposits have been determined. the first genetic model concerns the petrologic and geochemical processes and the other relates the genesis to crustal deformation and geodynamic conditions (kesler, 1997). recent studies (e.g., padilla garza et al., 2001) show that the generation and emplacement of porphyry copper deposits...

The assessment of de-desertification alternatives can be effective in controlling the reclamation of disturbed landand avoiding destruction of areas at risk. Until now, there has been no method to consider different criteria andalternatives, or to present the optimum alternatives based on systematic structures and experts’ perspectives.Desertification is a complex process resulting from various...

Patients with acute type B aortic dissection (ABAD) are often treated medically. However, ABAD is a potentially serious emergency if complicated by acute organ ischemia. The therapeutic strategy for ABAD with visceral malperfusion remains controversial. Because emergent surgery has a high mortality rate, emergent endovascular treatment can be performed instead. We report a case of endovascular ...

Patients with uncomplicated acute type B aortic dissection (ABAD) can generally be treated with conservative medical management. However, these patients may develop aortic enlargement during follow-up, with the risk of rupture. Several predictors have been studied in recent years to identify ABAD patients at high risk of aortic enlargement, who may benefit from early surgical or endovascular in...