Aim: The objective of this work was to study the effects of formulation variables on the release kinetics of paracetamol tablet formulation. Materials and Methods: Paracetamol tablets were formulated using wet granulation (WG) and direct compression (DC) using two predetermined pressures. Avicel, dicalcium phosphate (DCP) and pregelatinized starch (PGS) were used as directly compressible...

The objectives of present investigation were to achieve immediate release of paracetamol and tailored release of diclofenac sodium from bi-layer tablets. A 2(3) full factorial design was adopted using the amount of polyethylene glycol, microcrystalline cellulose and crospovidone as independent variables for fabricating paracetamol tablets. Diclofenac sodium tablets were prepared using hydroxypr...

It is a well-known fact that tablets are the most ordinary medicines in daily practice, which along with capsules represents about 70% of pharmaceutical preparations. Experimenting with paracetamol tablets of 500 mg dose was scope of this study. Study of formulation, preparation, quality control, and follow-up of the paracetamol stability in tablets was conducted. Carefully analyzing the physic...

OBJECTIVE To evaluate the effects on suicidal behaviour of legislation limiting the size of packs of paracetamol and salicylates sold over the counter. DESIGN Before and after study. SETTING UK population, with detailed monitoring of data from five liver units and seven general hospitals, between September 1996 and September 1999. SUBJECTS People who died by suicidal or accidental overdos...

OBJECTIVES To compare the efficacy and safety of single versus combination non-prescription oral analgesics in community-derived people aged 40 years and older with chronic knee pain. METHODS A randomised, double-blind, four-arm, parallel-group, active controlled trial investigating short-term (day 10) and long-term (week 13) benefits and side-effects of four regimens, each taken three times ...

The aim of this work was to explore the possibility of utilizing BFI as a tool for classifying, grouping and ranking binders based on performance in ameliorating capping and lamination in paracetamol tablets. Binders from different origins (starches, celluloses, natural gums, and synthetic gums) were used via wet granulation at concentrations ranging from 1.0 12.5% w/w to make paracetamol table...

The study evaluated two novel coprocessed excipients (with two methods) as disintegrants in an orally disintegrating paracetamol tablet formulation. The tablets produced were assessed for mechanical properties with the use of friability and tensile strength while the release properties were assessed with wetting time, water absorption ratio, disintegration time and dissolution profile. The resu...

No: 687 Health and Hygiene 329 EVALUATION OF THE IMPACT OF TABLET SPLITTING ON THE ACCURACY OF DRUG DOSING H.S. Sellahewa and H.M.D.R. Herath* Department of Pharmacy, Faculty of Allied Health Sciences, University of Peradeniya, Sri Lanka *[email protected] Tablet splitting is commonly used in pharmacy practice. There are many reasons to split tablets such as to get the prescribed dose, to ad...

INTRODUCTION The hypothesis that paracetamol might increase the risk of asthma and other allergic diseases have gained support from a range of independent studies. However, in studies based in developed countries, the possibility that paracetamol and asthma are associated through aspirin avoidance is difficult to exclude. OBJECTIVES To explore this hypothesis among women in a developing count...

The combination of dextropropoxyphene and paracetamol, marketed as Distalgesic, once a popular analgesic, is now less commonly prescribed. Each tablet contains 32-5mg of dextropropoxyphene and 325mg of paracetamol. Overdoses with this preparation were common in the late seventies, though nowadays are rarely seen. ' Overdoses of as little as twenty tablets very often led to death within thirty m...