Ketotifen (Zaditen), a benzocycloheptathiophene derivative, is a new oral agent for treating asthma, with action similar in some respects to that of sodium cromoglycate. It is well established that sodium cromoglycate protects against antigen challenge by inhibiting the release of chemical mediators from mast cells. It also inhibits exerciseinduced bronchoconstriction and has bronchodilator pro...

This study compares between unmodified carbon paste (CPE; the paste has no ion pair) and polyvinyl chloride (PVC) membrane selective electrodes that were used in potentiometric determination of ketotifen fumarate (KTF), where sodium tetraphenylborate (NaTPB) was used as titrant. The performance characteristics of these sensors were evaluated according to IUPAC recommendations which reveal a fas...

Mast cells in inflammation, fibrosis and hypersensitivity involved. Ketotifen is a member of allergy medication that reduces inflammation. The purpose of this study was to evaluate the effect of Ketotifen on some reproductive hormones, spermatogenesis, and immune parameters in male rats. A total of 75male mice of Balb / C were selected and randomly divided into15 groups and kept in the five cag...

The antiallergic drug ketotifen is chiral due to a nonplanar seven-membered ring containing a keto group. Earlier studies have revealed glucuronidation at the tertiary amino group as a major metabolic pathway in humans. Chemical synthesis of glucuronides from racemic ketotifen now led to four isomers separable by HPLC of which two each could be ascribed to (R)-(+)- and (S)-(-)-ketotifen by synt...

Background: Ketotifen blocks histamine H1 receptors, stabilises mast cells, and prevents eosinophil accumulation. These multiple, pharmacological mechanisms provided the rationale for assessing the efficacy and safety of ketotifen 0.025% eye drops in subjects with seasonal allergic conjunctivitis (SAC) in an environmental setting. Methods: This was a double masked, randomised, multicentre trial...

BACKGROUND Ketotifen blocks histamine H(1) receptors, stabilises mast cells, and prevents eosinophil accumulation. These multiple, pharmacological mechanisms provided the rationale for assessing the efficacy and safety of ketotifen 0.025% eye drops in subjects with seasonal allergic conjunctivitis (SAC) in an environmental setting. METHODS This was a double masked, randomised, multicentre tri...

BACKGROUND Oral immunotherapy (OIT) has shown promise in inducing desensitization for food allergy. However, there are safety concerns regarding the frequency and severity of adverse events during food OIT. OBJECTIVE To evaluate the effect of Ketotifen premedication on adverse reactions during peanut OIT. METHODS A randomized single blind placebo controlled pilot study was performed. Peanut...

This research has studied equilibrium adsorption isotherms of Ketotifen on carbon nanotube. And also results of experiments through Freundlich,Temkin and Langmuir models have been studied and it has found different parameters of these models for carbon nano-tube adsorbent. According to the error rate for each model, we obtained a good agreement between these data which it showed the best agreem...

The efficacy of ketotifen, a tricyclic benzocycloheptathiophene derivative, was assessed in an outpatient clinical trial and in a group of 12 asthmatic subjects with exercise-induced asthma. Subjects in the outpatient trial had mild asthma and consisted of two groups: a group of 24 atopic asthmatics with at least one positive skin test reaction and with an associated history of bronchial reacti...