نتایج جستجو برای: KLK4

تعداد نتایج: 179  

2013
Ying Dong Carson Stephens Carina Walpole Joakim E. Swedberg Glen M. Boyle Peter G. Parsons Michael A. McGuckin Jonathan M. Harris Judith A. Clements

High tumor kallikrein-related-peptidase 4 (KLK4) levels are associated with a poor outcome for women with serous epithelial ovarian cancer (EOC), for which peritoneal dissemination and chemoresistance are key events. To determine the role of KLK4 in these events, we examined KLK4-transfected SKOV-3 and endogenous KLK4 expressing OVCA432 cells in 3-dimensional (3D) suspension culture to mimic th...

2016
Yuanyuan Hu Charles E. Smith Amelia S Richardson John D. Bartlett Jan C.C. Hu James P. Simmer

Matrix metalloproteinase 20 (MMP20) and kallikrein-related peptidase 4 (KLK4) are secreted proteinases that are essential for proper dental enamel formation. We characterized and compared enamel formed in wild-type, Mmp20 (-/-), Klk4 (-/-), Mmp20 (+/-) Klk4 (+/-), and Mmp20 (-/-) Klk4 (-/-) mice using dissecting and light microscopy, backscattered scanning electron microscopy (bSEM), SEM, micro...

Journal: :The Prostate 2005
Masazumi Matsumura Ami S Bhatt Dennis Andress Nigel Clegg Thomas K Takayama Charles S Craik Peter S Nelson

BACKGROUND Prostase/KLK4 is a member of the human kallikrein (KLK) gene family that is expressed in prostate epithelial cells under the regulation of androgenic hormones. In this study, we sought to characterize the substrate specificity of KLK4 in order to gain insight into potential physiological roles of the enzyme. METHODS A chimeric form of KLK4 was constructed in which the pro-region of...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2001
C V Obiezu A Scorilas D Katsaros M Massobrio G M Yousef S Fracchioli I A Rigault de la Longrais R Arisio E P Diamandis

PURPOSE Kallikrein gene 4 (KLK4, also known as prostase/KLK-L1), located on chromosome 19q13.4, is one of the newly discovered members of the human KLK-like gene family. This gene is up-regulated by androgens in the LNCaP prostatic carcinoma cell line and by androgens and progestins in the BT-474 breast cancer cell line. On the basis of its apparent association with hormonally regulated tissues...

Journal: :Journal of immunology 2002
John A Hural Rachel S Friedman Andria McNabb Sean S Steen Robert A Henderson Michael Kalos

Kallikrein (KLK)4 is a recently described member of the tissue kallikrein gene family that is specifically expressed in normal and prostate tumor tissues. The tissue-specific expression profile of this molecule suggests that it might be useful as a vaccine candidate against prostate cancer. To examine the presence of CD4 T cells specific for KLK4 in PBMC of normal individuals, a peptide-based i...

Journal: :Cancer research 2007
Tove Irene Klokk Anette Kilander Zhijun Xi Håkon Waehre Bjørn Risberg Håvard E Danielsen Fahri Saatcioglu

Kallikrein 4 (KLK4) is a member of the human tissue KLK family. Whereas all other KLKs are secreted proteins with extracellular functions, KLK4 is primarily localized to the nucleus, indicating that it has a different function compared with other members of the KLK family. In addition, KLK4 expression is highly enriched in the prostate and is regulated by androgens. Here, we studied the possibl...

Journal: :European journal of oral sciences 2011
Yasuo Yamakoshi Amelia S Richardson Stephanie M Nunez Fumiko Yamakoshi Rachel N Milkovich Jan C-C Hu John D Bartlett James P Simmer

Matrix metalloproteinase 20 (MMP20) and kallikrein-related peptidase 4 (KLK4) are thought to be necessary to clear proteins from the enamel matrix of developing teeth. We characterized Mmp20 and Klk4 null mice to better understand their roles in matrix degradation and removal. Histological examination showed retained organic matrix in Mmp20, Klk4, and Mmp20/Klk4 double-null mouse enamel matrix,...

Journal: :Molecular cancer research : MCR 2009
John Lai Stephen A Myers Mitchell G Lawrence Dimitri M Odorico Judith A Clements

Kallikrein 4 (KLK4) is a member of the human KLK gene family of serine proteases, many of which are implicated in hormone-dependent cancers. Like other KLKs, such as KLK3/PSA and KLK2, KLK4 gene expression is also regulated by steroid hormones in hormone-dependent cancers, although the transcriptional mechanisms are ill defined. Here, we have investigated the mechanisms mediating the hormonal r...

Journal: :European journal of oral sciences 2011
Yasuo Yamakoshi Fumiko Yamakoshi Jan C-C Hu James P Simmer

Kallikrein-related peptidase 4 (KLK4) is a glycosylated serine protease that functions in the maturation (hardening) of dental enamel. Pig and mouse KLK4 contain three potential N-glycosylation sites. We isolated KLK4 from developing pig and mouse molars and characterized their N-glycosylations. N-glycans were enzymatically released by digestion with N-glycosidase F and fluorescently labeled wi...

2012
Felicity Lose Srilakshmi Srinivasan Tracy O’Mara Louise Marquart Suzanne Chambers Robert A. Gardiner Joanne F. Aitken Trina Yeadon Pamela Saunders Allison Eckert Judith Clements Peter Heathcote Glenn Wood Greg Malone Hema Samaratunga Angus Collins Megan Turner Kris Kerr Amanda B. Spurdle Jyotsna Batra Judith A. Clements

The Kallikrein-related peptidase, KLK4, has been shown to be significantly overexpressed in prostate tumours in numerous studies and is suggested to be a potential biomarker for prostate cancer. KLK4 may also play a role in prostate cancer progression through its involvement in epithelial-mesenchymal transition, a more aggressive phenotype, and metastases to bone. It is well known that genetic ...

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