RECK is a membrane-anchored glycoprotein which may negatively regulate matrix metalloproteinase (MMP) activity to suppress tumor invasion and metastasis. In this study, recombinant proteins corresponding to the residues 285-368 (named as CKM which contained cysteine knot motif), 605-799 (named as K123 which contained three Kazal motifs), 676-799 (named as K23 which contained the last two Kazal ...

BACKGROUND How the productivity and careers of KL2 scholars compare with scholars receiving individual K-awards is unknown. METHODS The productivity of KL2 scholars (n=21) at our institution was compared with that of K08 (n=34) and K23 (n=26) scholars. RESULTS KL2 and K23 scholars had greater productivity than K08 scholars (p=0.01). Professional advancement was similar among groups. CONCL...

The first National Institutes of Health (NIH) grant awarded to physician scientists is often a K08 or K23 award. This chapter is designed for the Hematology Fellow who is preparing for an independent faculty position in 3-5 years. The topics covered include deciding which award to apply for, advice about planning and writing the application, as well as a description of the review process and ho...

in 0.1 M ionic strength aqueous solution at 120 for the following: 2,4-dihydroxy4'-nitroazobenzene (I), 2,4-dihydroxy-4'-sulfonateazobenzene (II), and p-(2hydroxy-l-naphthylazo) benzenesulfonic acid (III). The reported values of k231 were 4O X 105, 3.6 X 105, and 3.6 X 106 M-1 sec-1. They attributed the much lower values of k23, for these acids than the value3 k23, 2 X 109 M-1 sec-1 kn,' for th...

Southern hybridization analysis of the genomes from the newly-isolated 10 carbazole (CAR)-utilizing bacteria revealed that 8 of the isolates carried gene clusters homologous to the CAR-catabolic car operon of Pseudomonas resinovorans strain CA10. Sequencing analysis showed that two car operons and the neighboring regions of Pseudomonas sp. strain K23 are nearly identical to that of strain CA10....

OBJECTIVE In the pancreatic beta-cell, ATP-sensitive K(+) (K(ATP)) channels couple metabolism with excitability and consist of Kir6.2 and SUR1 subunits encoded by KCNJ11 and ABCC8, respectively. Sulfonylureas, which inhibit the K(ATP) channel, are used to treat type 2 diabetes. Rare activating mutations cause neonatal diabetes, whereas the common variants, E23K in KCNJ11 and S1369A in ABCC8, ar...

UNLABELLED Studies evaluating the immunogenicity of two pediatric tick-borne encephalitis virus (TBEV) vaccines have reported contradictory results. These vaccines are based on two different strains of the European TBEV subtype: FSME-Immun Junior is based on the Neudörfl (Nd) strain, whereas Encepur Children is based on the Karlsruhe (K23) strain. The antibody (Ab) response induced by these two...

An outerplanar graph is a planar graph which can be embedded in the plane such that all nodes lie on the outer face. A series-parallel graph is a graph which is the result of series (subdivision) or parallel (doubling) extensions of the edges of a forest. (Both graph families can be described via families of forbidden minors {K4,K23} and {K4}, respectively, where K4 denotes the complete graph o...

Pancreatic β-cell ATP-sensitive K(+) (K(ATP)) channels are composed of Kir6.2 and SUR1 subunits encoded by the KCNJ11 and ABCC8 genes, respectively. Although rare monogenic activating mutations in these genes cause overt neonatal diabetes, the common variants E23K (KCNJ11) and S1369A (ABCC8) form a tightly heritable haplotype that is associated with an increased susceptibility to type 2 diabete...

To investigate the role of E23K polymorphism of the KCNJ11 gene on early onset of type 2 diabetes in school-aged children/adolescents in Taiwan, we recruited 38 subjects with type 2 diabetes (ages 18.6 ± 6.6 years; body mass index percentiles 83.3 ± 15.4) and 69 normal controls (ages 17.3 ± 3.8 years; body mass index percentiles 56.7 ± 29.0) from a national surveillance for childhood/adolescent...