Coronaviruses raise serious concerns as emerging zoonotic viruses without specific antiviral drugs available. Here we screened a collection of 16671 diverse compounds for anti-human coronavirus 229E activity and identified an inhibitor, designated K22, that specifically targets membrane-bound coronaviral RNA synthesis. K22 exerts most potent antiviral activity after virus entry during an early ...

Electro-optic measurements were performed on a lamellar nematic phase in which the mesogenic moieties lie in lamellae that are separated by partially perfluorinated side groups. The twist elastic constant K22, viscosity gamma(1), and the quadratic and quartic anchoring strength coefficients are reported. K22 and gamma(1) are found to be considerably smaller than that of typical three-dimensiona...

Spontaneous, informal gatherings among colleagues often spur greater exchanges of ideas than formal meetings. The K22 project aims to support these spontaneous collaborative interactions by embedding intelligent kiosks, small networked Intelligent Environments (IEs), in hallways, break rooms, and other informal meeting spaces. These kiosks will enable private capture and indexing of casual meet...

We demonstrate a simple method for measuring the twist elastic constant (K22) of a nematic liquid crystal (LC). By adding some chiral dopant to an LC host, the LC directors rotate 180° in a homogeneous cell, which is known as 180° super-twisted nematic (STN) cell. By preparing two such STN cells with different chiral concentrations and measuring their Fréedericksz threshold voltages, we can obt...

The taxonomic position of a bacterium isolated from a cold desert of the Himalayas, India, was analysed by using a polyphasic approach. The isolated strain, designated K22-03T, had phenotypic characteristics that matched those of the genus Planococcus and it represents a novel species. The almost-complete 16S rRNA gene sequence (1464 bases) of the novel strain was compared with those of previou...

Strain K22(T) is the type species of the recently- described genus Pyrinomonas, in subdivision 4 of the phylum Acidobacteria (Int J Syst Evol Micr. 2014; 64(1):220-7). It was isolated from geothermally-heated soil from Mt. Ngauruhoe, New Zealand, using low-nutrient medium. P. methylaliphatogenes K22(T) has a chemoheterotrophic metabolism; it can hydrolyze a limited range of simple carbohydrates...

In this study, optimal diffusion coefficients for Lake Zirahuén, Mexico, were found under particular conditions based on images taken with a drone of dye release experiment. First, the patch concentration was discretized using image processing tools, and it then approximated by an ellipse, finding major minor axes. The inverse problem implemented comparing these observational data obtained nume...

In this work, we proposed a new approach called integer sub-decomposition (ISD) based on the GLV idea to compute any multiple kP of a point P of order n lying on an elliptic curve E. This approach uses two fast endomorphisms ψ1 and ψ2 of E over prime field Fp to calculate kP. The basic idea of ISD method is to sub-decompose the returned values k1 and k2 lying outside the range √ n from the GLV ...

There are two classes of liquid crystals (LCs): Thermotropic LCs where the organic molecule represents anisotropically shaped mesogen and lyotropic LCs, mesogens non-spherical supramolecular assemblies dispersed in a solvent. Various kinds nematic (LLCs) exist, differing shape composition aggregates: Chromonic, polymeric or micellar LLCs.However, LLCs most ubiquitous kind LLCs, occurring soaps ...