The aim of this study was to evaluate the immunogenicity and efficacy of Montanide ISA 720 against BCG and alum as an adjuvant for Leishmania killed vaccine in BALB/c mice. Groups of mice were immunized with either, Baccile Calmette Guerin (BCG), aluminium hydroxide (alum) or Montanide ISA 720 (MISA) with killed Leishmania major (KLM) promastigotes antigen and later, sacrificed or challenged wi...

Anti-mesothelin Pseudomonas exotoxin A-based recombinant immunotoxins (RITs) present a potential treatment modality for pancreatic ductal adenocarcinoma (PDAC). To study mechanisms of resistance, the sensitive PDAC cell line KLM-1 was intermittently exposed to the anti-mesothelin SS1-LR-GGS RIT. Surviving cells were resistant to various anti-mesothelin RITs (IC50s >1 μg/ml), including the novel...

The Keystroke Level Model (KLM) and Fitts’ Law constitute core teaching subjects in most HCI courses, as well as many courses on software design and evaluation. The KLM Form Analyzer (KLM-FA) has been introduced as a practitioner’s tool to facilitate web form design and evaluation, based on these established HCI predictive models. It was also hypothesized that KLMFA can also be used for educati...

The immune responses of mice immunized with ovalbumin (OVA) together with killed L. major (KLM) promastigotes as adjuvant were studied. Three doses (5 × 107, 1 × 108 and 2 × 108) of KLM combined with OVA (100 mg) were injected into the groups of C57BL/6 mice. BCG and complete Freund’s adjuvant (CFA) were used as control adjuvants. Lymphocyte proliferation and antibody titers were determined, an...

The immune responses of mice immunized with ovalbumin (OVA) together with killed L. major (KLM) promastigotes as adjuvant were studied. Three doses (5 × 10, 1 × 10 and 2 × 10) of KLM combined with OVA (100 g) were injected into the groups of C57BL/6 mice. BCG and complete Freund’s adjuvant (CFA) were used as control adjuvants. Lymphocyte proliferation and antibody titers were determined, and I...

A human round cell line, KLM-2, is considered to be precursor B-cell by immunologic surface marker analysis and histochemical studies. The effect of 12-O-tetradecanoyl phorbol-13-acetate (TPA) and/or colony-stimulating factor (CSF) on KLM-2 cells was investigated. KLM-2 cells became adherent to the bottom of the flask on day 2 after liquid culture with TPA, and the number of macrophage-like adh...

We present proof methods for the logics of nonmonotonic reasoning defined by Kraus, Lehmann and Magidor (KLM). We introduce tableaux calculi (called T S) for all KLM logics. We provide decision procedures for KLM logics based on these calculi, and we study their complexity. Finally, we describe KLMLean 2.0, a theorem prover implementing the calculi T S inspired by the “lean” methodology. KLMLea...

The purpose of this research is to identify and evaluate the accounts receivable control system adopted by PT KLM. This conducted using qualitative methodology. There are both primary secondary data used. Using interview observation tactics obtain from store managers, cashiers, billing parties for publishing articles. investigation was done at KLM office in Lamongan, East Java. On basis finding...

the immune responses of mice immunized with ovalbumin (ova) together with killed l. major (klm) promastigotes as adjuvant were studied. three doses (5 × 107, 1 × 108 and 2 × 108) of klm combined with ova (100 mg) were injected into the groups of c57bl/6 mice. bcg and complete freund’s adjuvant (cfa) were used as control adjuvants. lymphocyte proliferation and antibody titers were determined, an...

A Kerr-lens mode-locked (KLM) Yb:YAG thin-disk oscillator delivering 215-fs pulses with 75-W average power and 1.4-MW peak power at a repetition rate of 260 MHz is presented. Self-starting KLM is demonstrated at an output power of 68 W. This is the highest repetition rate of any mode-locked thin-disk oscillators so far. Concepts for scaling the repetition rate up to 1 GHz are discussed.