an 8-year-old female japanese spitz dog was reffered to shiraz university veterinary clinic, with signof anisocoria. clinical examinations revealed mydriasis in the right eye. ocular examination revealed adilated and unresponsive right pupil to focal illumination. by testing with topical 2% pilocarpine, thetentative diagnosis was parasympathetic denervation of the right iris sphincter muscle—pu...

An 8-year-old female Japanese Spitz dog was reffered to Shiraz University Veterinary Clinic, with signof anisocoria. Clinical examinations revealed mydriasis in the right eye. Ocular examination revealed adilated and unresponsive right pupil to focal illumination. By testing with topical 2% pilocarpine, thetentative diagnosis was parasympathetic denervation of the right iris sphincter muscle—pu...

A 23-year-old female presented with a reddish-brown dome-shaped hyperkeratotic nodule of 11 × 10 mm on the left lower leg. Dermoscopic examination demonstrated a prominent whitish scaly area with ring-like appearance, pinkish-white structureless areas, a few milia-like cysts, dotted and glomerular vessels, and light brown globules. The lesion was completely excised under the diagnosis of verruc...

*Corresponding Author Yugal Raj Bindari [email protected] This paper reports on a case of canine fetal mummification which is very rare. A Japanese Spitz aged 5 year was brought to the clinic of Mount Everest Kennel Club. Breeding history of dog was obtained from the owner. X-ray confirmed the presence of fetus. Exploratory laparotomy was done under general anesthesia. Five mummified fetus...

Drosophila Spitz is a homolog of transforming growth factor alpha (TGF-alpha) and is an activating ligand for the EGF receptor (Egfr). It has been shown that Star is required for Spitz activity. Here we show that Star is quantitatively limiting for Spitz production during eye development. We also show that Star and Spitz proteins colocalize in Spitz sending cells and that this association is no...

Spitz nevus is a variant of melanocytic nevus which is histopathologically defined as large spindle and/or epithelioid cells. Angiomatoid Spitz nevus is a rare histologic variant of desmoplastic Spitz nevus characterized by prominent vasculature. We present a case of angiomatoid Spitz nevus, celluar type, that has not been reported before. We provide another example to show the remarkable diver...

The Spitz nevus was first described as the “melanoma of childhood” or “juvenile melanoma” by Sophie Spitz in 1948 (1). Most spitzoid melanocytic proliferations can be classified as benign Spitz nevi or spitzoid melanomas based on published criteria (2-3). However, a subset of spitzoid lesions have histological features that deviate from a typical Spitz nevus, yet are insufficient for a definiti...

BACKGROUND It is unclear whether pigmented Spitz and Reed nevi are distinct morphologic entities or part of the spectrum of Spitz nevi. METHODS In a retrospective observational study we analyzed dermatopathologic slides of 22 cases with clinical and dermatoscopic features indicative of pigmented Spitz or Reed nevus in a blinded fashion according to predefined criteria and subsequently correla...

OBJECTIVE Despite recent advances in our molecular understanding of Spitz-type tumors, the clinical behavior of these lesions remains unclear. We thus set out to define the clinical outcome of classic Spitz nevi, atypical Spitz tumors (ASTs), and spitzoid melanomas. DESIGN From 1987 through 2002, data on all lesions containing the term "Spitz" or "Spitz" [AND] "melanoma" were retrieved from t...

AIMS Spitz naevi are difficult to diagnose, because of significant overlap with melanomas. It has been recently demonstrated that the LSI RREB1(6p25)/LSI MYB(6q23)/LSI CCND1(11q13)/CEP6 fluorescence in-situ hybridization (FISH) assay is a reliable tool with which to distinguish benign naevi and melanomas. Little is known about its diagnostic usefulness in Spitz naevi. METHODS AND RESULTS We i...