We previously reported that stimulation of the vagus nerve attenuates macrophage responses by activating the intracellular Jak2-STAT3 signaling pathway. Here, we further analyzed the potential of STAT3 to modulate TNF responses using STAT silencing strategies, pharmacological blockade, and dominant negative STAT3 constructs. We reveal that deletion of STAT3 using siRNA strategies augments the T...

A complete blood count performed in chronic hepatitis C virus (HCV) infected patients can identify thrombocytopenia or an increased number of platelets, the cause of which must be established. Most of these patients are predisposed to develop thrombocytopenia as the disease progresses due to a lower thrombopoietin production, increased platelet pooling in the spleen, viral bone marrow suppressi...

Pathogenic mutations in JAK2, MPL or calreticulin associated with activated JAK/STAT3/5 signaling are a common feature in Myeloproliferative Neoplasms (MPNs) [1]. Pivotal clinical trials confirmed the activity, leading to FDA approval, of the type I JAK1/2 inhibitor ruxolitinib as therapy for advanced MPN-Myelofibrosis (MF) and Polycythemia Vera [1]. Ruxolitinib confers notable clinical benefit...