roaccutaneâ® (isotretinoin) is used for the treatment of severe forms of acne resistant to adequate standard therapy. inflammatory bowel disease (ibd) is described as a possible adverse drug reaction in the product information of isotretinoin. in a case study, we report the case of a 30 year old woman with a history of bloody diarrhea, abdominal pain and severe folliculitis/acne which had been ...

acne is the most common skin disease and isotretinoin is the most powerful drug among the various drugs used for its treatment, but it has some adverse effects. the aim of this study was to evaluate the effect of isotretinoin on depression and quality of life of a group of patients undergoing isotretinoin therapy before and after the treatment course.in this prospective study, 98 patients with ...

BACKGROUND Isotretinoin (13-cis retinoic acid) is a metabolite of vitamin A and has anti-inflammatory and immunoregulatory effects; however, a recent publication by DePaolo et al. demonstrated that in the presence of IL-15, retinoic acid can act as an adjuvant and promote inflammation against dietary proteins. OBJECTIVE To evaluate the risk of overt and latent celiac disease (CD) among users ...

The present paper demonstrates the increased photostability of isotretinoin when loaded in microemulsion. The photodegradation of isotretinoin, in methanol and microemulsion formulation was studied under direct sun light. The photodegradation process was monitored by UV spectrophotometry. In methanol solution, isotretinoin undergoes complete photodegradation just within a few minutes of light e...

30-yr-old patient who was treated with isotretinoin for 3 months (5). The third report describes the successful treatment of acne vulgaris in a 13-yr-old patient who was treated with isotretinoin for 5 months (6). In none of the reports, the authors provide information on the concentration of itraconazole in blood of their patients while on comedication with isotretinoin, so we suspect that the...

BACKGROUND Isotretinoin, a teratogen, is widely used to treat cystic acne. Although the risks of pregnancy during isotretinoin therapy are well recognized, there are doubts about the level of adherence with the pregnancy prevention program in Canada. Our objective was to evaluate the effectiveness of the Canadian pregnancy prevention program in 4 provinces: British Columbia, Saskatchewan, Manit...

Isotretinoin is a vitamin A derivative that has been commonly used by dermatologists for the treatment of acne. Isotretinoin has many dose-related side-effects, which have caused many debates lately, especially related to psychiatric and gastrointestinal issues. Since the introduction of isotretinoin into the market, there have been a growing number of reported cases of psychiatric side-effects...

Current practice guidelines recommend administration of oral isotretinoin with high-fat meals, which may pose issues with patient compliance. Isotretinoin-Lidose (Epuris™), approved by Health Canada in November 2012 and scheduled for commercial release June 2013, is based on novel lipid encapsulation technology (Lidose®) to enclose isotretinoin, thereby increasing drug absorption during fasted ...

OBJECTIVE To estimate isotretinoin exposure in Dutch pregnant women despite the implemented pregnancy prevention programme (PPP) and second, to analyse the occurrence of adverse fetal or neonatal outcomes in these isotretinoin exposed pregnancies. DESIGN Population-based study. SETTING The Netherlands. PARTICIPANTS A cohort of 203,962 pregnancies with onset between 1 January 1999 and 1 Se...

Purpose The aims of the study were to evaluate medication adherence and the influencing factors for isotretinoin and contraception (oral, patches, and rings) and to evaluate the concomitant use of contraception and isotretinoin. Methods Reimbursed prescription data from January 2012 to August 2015 of all patients in Belgium were received from Pharmanet-National Institute for Health and Disabi...