the stimulatory effect of the extract of portulaca oleracea (p. olerace) on β-adrenoceptor of tracheal smooth muscle was examined. to examine β-adrenoceptor stimulatory effect, concentration response curve to isoprenaline was obtained in pre-contracted tracheal smooth muscle in the presence of three concentrations of aqueous-ethanolic extract, propranolol and saline. values of ec50 (the effecti...

Background and Purpose Oxidative stress fibrosis are hallmarks of cardiomyopathy-induced heart failure yet not effectively targeted by current frontline therapies. Here, the therapeutic effects anti-oxidant, N-acetylcysteine (NAC), were compared combined with an acute drug established anti-fibrotic effects, serelaxin (RLX), in a murine model cardiomyopathy. Experimental Approach Adult male 129s...

Cardioprotective role of intravenous administration of magnesium chloride was evaluated in rabbits by biochemical and histopathological parameters. Myocardial damage was induced by injecting (i.v.) isoprenaline 1, 2.5, 5 and 7.5 mg/kg body weight of animal. There was a dose dependent increase in the activity of cardiac enzyme creatinine kinase CK (C Max). Maximal elevation of CK (C Max) was obs...

Objective(s) In the present study, the effects of aqueous-ethanolic extract from Rosa damascena on heart rate and contractility were examined. Materials and Methods Isolated guinea-pig hearts were perfused through aorta in a Langendorff mode. Heart rate (HR) and contractility were determined in the presence of four concentrations of the extract (0.1, 0.2, 0.4 and 1.0 mg %) and isoprenaline (...

OBJECTIVES To examine the effect of isoprenaline on slow and fast pathway properties and tachycardia initiation. DESIGN Consecutive patients, prospective study. SETTING Referral centre for cardiology, academic hospital. PATIENTS 24 patients suffering from common type atrioventricular nodal reentrant tachycardia (AVNRT). INTERVENTIONS Programmed electrical stimulation and radiofrequency ...

The relaxing effect of isoprenaline on [Na+]o-free induced contracture of the guinea-pig taenia coli was investigated in presence of phentolamine (10(-5)M), an alphareceptor blocking agent. This action of isoprenaline showed dose-dependency (ED 50: 10(-5)M) and was abolished completely by beta-receptor blocking agent (propranolol, 10(-5)M). The effect of isoprenaline (10(-5)M) disappeared gradu...

objective(s) in the present study, the effects of aqueous-ethanolic extract from rosa damascena on heart rate and contractility were examined. materials and methods isolated guinea-pig hearts were perfused through aorta in a langendorff mode. heart rate (hr) and contractility were determined in the presence of four concentrations of the extract (0.1, 0.2, 0.4 and 1.0 mg %) and isoprenaline (1, ...

The present investigation was directed to study the effect of in vitro or ex vivo NO donors, sodium nitroprusside and molsidomine, using isolated sliced adipose tissue or in the form of immobilized and perfused adipocytes on the basal and isoprenaline-stimulated lipolysis. The results demonstrated that 1) in vitro application of sodium nitroprusside to perfused adipocytes or molsidomine to slic...

Object We aimed to identify the β-adrenoceptor (β-AR) subtypes involved in isoprenaline-induced relaxation of guinea pig colonic longitudinal smooth muscle using pharmacological and biochemical approaches. Methods Longitudinal smooth muscle was prepared from the male guinea pig ascending colon and contracted with histamine prior to comparing the relaxant responses to three catecholamines (isopr...

Commiphora mukul commonly known as Guggul is one of the oldest and commonly consumed herb for promoting heart and vascular health. Present study was undertaken to evaluate cardioprotective potential of Commiphora mukul against isoprenaline-induced myocardial necrosis in rats. Wistar albino rats were divided into three main groups: sham (saline only), isoprenaline control (saline and isoprenalin...