a new alkaloid (1) and two known compounds (2 and 3) were isolated from the blue-greenalga arthrospira platensis. their structures were determined on the basis of spectroscopic data.according to the obtained data and values in the literature, the compounds were concluded to beeckol.

A novel C-homoprotoberberine alkaloid, Hediamine (2), has been isolated from the roots of Berberis actinucantha (Berberidaceae). Conclusive proof for the structure of hediamine was obtained by its comparison with the isomeric lactam (4), by chemical transformation, and by means of spectroscopic techniques (UV, IR, MS, NMR).

Natural products provide excellent potential leads for drug development because of their chemical diversity and biological functionality. However, the productivity of discovery of new, pharmacologically active natural products has traditionally been low due to inherent difficulties and costs associated with extract dereplication, i.e., isolation, purification and structure elucidation of indivi...

Natural products provide excellent potential leads for drug development because of their chemical diversity and biological functionality. However, the productivity of discovery of new, pharmacologically active natural products has traditionally been low due to inherent difficulties and costs associated with extract dereplication, i.e., isolation, purification and structure elucidation of indivi...

a novel c-homoprotoberberine alkaloid, hediamine (2), has been isolated from the roots of berberis actinucantha (berberidaceae). conclusive proof for the structure of hediamine was obtained by its comparison with the isomeric lactam (4), by chemical transformation, and by means of spectroscopic techniques (uv, ir, ms, nmr).

A fermentation broth of an unidentified fungus (N983-46) was found to produce DNAgyrase inhibitors, CJ-12,371 (1) and CJ-12,372 (2). Following isolation by solvent extraction and silica gel and ODS(reverse phase) chromatographies, the structures were determined to be novel spiro-ketal compounds with S-connguration at position C-l. CJ-12,371 and CJ-12,372 inhibit both DNA supercoiling and relaxa...