background: pancreatic islet transplantation has emerged as a promising treatment for type i diabetes. however, its efficacy is severely hampered due to poor islet engraftment and revascularization, which have been resulted to partially loss of transplanted islets. it has been shown that local delivery of vascular endothelial growth factor (vegf) could accelerate transplanted islet revasculariz...

Background: Pancreatic islet transplantation has emerged as a promising treatment for type I diabetes. However, its efficacy is severely hampered due to poor islet engraftment and revascularization, which have been resulted to partially loss of transplanted islets. It has been shown that local delivery of vascular endothelial growth factor (VEGF) could accelerate transplanted islet revasculari...

background: oral vanadyl sulfate (vanadium) induces normoglycemia, proliferates beta cells and prevents pancreatic islet atrophy in streptozotocin-induced diabetic rats. soteriological method is used to quantitate the proliferative effects of vanadium on beta-cell numbers and islet volumes of normal and diabetic rats. methods: adult male sprague-dawley rats were made diabetic with intravenous s...

abstract reactive oxygen species and oxidative stress impair β-cell function and reduce insulin secretion. it has been shown that progesterone and cilostazol possess antioxidant properties. the present study was aimed to investigate in vitro pretreatment effect of progesterone and cilostazol on insulin secretion as well as their protective effects against hydrogen peroxide-induced oxidative str...

conclusions our results indicated that the dissemination of pi-1 was widespread in s. pneumoniae isolates, although no pi-2 isolates were detected. furthermore, the frequency of rlra and rrgc of clinical isolates was significantly more than that of normal flora isolates. results the results confirmed the presence of rlra and rrgc genes in both clinical (n = 39) and normal flora (n = 26) isolate...

introduction: vanadium salts have been suggested as a possible therapeutic agent for the treatment of diabetes. the aim of the present study was to clarify immunohistochemical changes that occur in the pancreatic beta ([pancreatic islet beta]) cells of vanadyl sulphate (vs) treated stz induced diabetic rats. materials and methods: male wistar rats were made diabetic with injecting a single intr...

objective(s):some pathologic situations such as diabetes and metabolic syndrome are associated with alternation in nitric oxide level. incidence of these condition increases with aging. on the other hand, insulin secretion is modulated by nitric oxide, and nitric oxide synthase (nos) activity is also altered in diabetes. in this study, modification in the enzyme activity associated with aging a...