Meldrum, Kirstan K., Daniel R. Meldrum, Xianzhong Meng, Lihua Ao, and Alden H. Harken. TNF-dependent bilateral renal injury is induced by unilateral renal ischemiareperfusion. Am J Physiol Heart Circ Physiol 282: H540–H546, 2002; 10.1152/ajpheart.00072.2001.—While tumor necrosis factor (TNF)is an important mediator of renal ischemiareperfusion (I/R) injury, its role in contralateral renal injur...

BACKGROUND AND PURPOSE The dynamics of leukocyte infiltration in human cerebral ischemia were studied using technetium-99m hexamethylpropyleneamine oxime (99mTc HMPAO)-labeled leukocyte brain single-photon emission computed tomography (SPECT). METHODS Twenty-two patients diagnosed as having hemispheric ischemic stroke were examined with 99mTc HMPAO brain SPECT for cerebral blood flow study an...

vascular adhesion protein-1 (vap-1) is an endothelial cell surface-expressed oxidase involved in leukocyte traffic. the adhesive function, and therefore leukocyte infiltration to different tissues, can be blocked by anti-vap-1 antibodies as well as small molecule vap-1 inhibitors. several papers have been published on the effect of vap-1 blockade on both leukocyte accumulation into tumors and n...

OBJECTIVES We sought to discover which types of injuries were related to human leukocyte antigen DR expression in acute rejection and late chronic injury in renal allografts. MATERIALS AND METHODS Ninety-two recipients were separated into the early acute rejection group, the late monocyte infiltration group, and the late chronic injury group. Ten subjects with acute cellular rejection receive...

background: the aim of this study was to investigate the protective effects of crocin against tissue damages and leukocyte infiltration induced by renal ischemia/reperfusion. methods: in this experimental study, 35 male wister rats weighing 250-300 g were randomly divided into 5 groups; 1. operated controls, but no vessel occlusion was considered and passed during equivalent reperfusion period ...

PURPOSE This study was designed to investigate the suppressive effects of antithrombin (AT)III on inflammatory reactions during endotoxin-induced uveitis (EIU) in rats by studying leukocyte-endothelium interactions. METHODS EIU was induced in Lewis rats by footpad injection of lipopolysaccharide (LPS). ATIII was administered immediately after or at 6 hours after LPS injection. Its suppressive...

Objectives: Curcumin has anti-inflammatory and antioxidative properties. The objective of this study was to investigate the therapeutic effects of curcumin on functional disturbances, oxidative stress, and leukocyte infiltration induced by renal ischemia/reperfusion (I/R). Materials and Methods: Animals were randomly divided into 9 groups. The groups with 24-h reperfusion consisted of sham-24h,...