in this study, a rapid, simple and sensitive ion mobility spectrometry (ims) method with corona discharge as ionization source was described for the morphine determination in human urine. morphine was extracted and purified from urine samples using solid phase extraction procedure with c18 column. it can offer the clean extracts which no extra peaks were observed in ims. under operating experim...

Carbohydrates are characterized by a truly remarkable level of structural diversity which stands in accord with a corresponding functional diversity arguably unsurpassed by any other class of biomolecule. As metabolites, structural components, mediators of molecular interaction, and modifiers of other biomolecules, carbohydrates play central roles in numerous areas of biochemistry. Detailed mol...

MOTIVATION The addition of ion mobility spectrometry to liquid chromatography-mass spectrometry experiments requires new, or updated, software tools to facilitate data processing. RESULTS We introduce a command line software application LC-IMS-MS Feature Finder that searches for molecular ion signatures in multidimensional liquid chromatography-ion mobility spectrometry-mass spectrometry (LC-...

The development of a new ion mobility/mass spectrometry instrument that incorporates a multifield drift tube/ion funnel design is described. In this instrument, individual components from a mixture of ions can be resolved and selected on the basis of mobility differences prior to collisional activation inside the drift tube. The fragment ions that are produced can be dispersed again in a second...

Multidimensional ion mobility spectrometry (IMS-IMS and IMS-IMS-IMS) techniques have been combined with mass spectrometry (MS) and investigated as a means of generating and separating peptide and protein fragment ions. When fragments are generated inside a drift tube and then dispersed by IMS prior to MS analysis, it is possible to observe many features that are not apparent from MS analysis al...

Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA Abstract The use of ion-mobility spectrometry (IMS) coupled to mass spectrometry (IMS–MS) for biomolecule analyses has steadily increased over the past two decades, and is now applied to both proteomic and metabolomic investigations. This chapter describes the application of traveling-wave ion-mobility spectrometry–mass ...

Ion mobility spectrometry (IMS) coupled to mass spectrometry (MS) has seen spectacular growth over the last two decades. Increasing IMS sensitivity and capacity with improvements in MS instrumentation have driven this growth. As a result, a diverse new set of techniques for separating ions by their mobility have arisen, each with characteristics that make them favorable for some experiments and...

Ion mobility spectrometry (IMS) has potential analytical applications in very diverse fields such as chemical, petrochemical, environmental, and, more recently, in drug, chemical warfare agent, and explosives detection. Commercially available IMS instruments are based on time-of-flight (TOF) mass spectrometry. IMS is inherently suitable for field operation as it uses relatively simple microflui...

RATIONALE Ion mobility spectrometry-mass spectrometry (IMS-MS) offers an opportunity to combine measurements and/or calculations of the collision cross-sections and subsequent mass spectra with computational modelling in order to derive the three-dimensional structure of ions. IMS-MS has previously been reported to separate two components for the compound norfloxacin, explained by protonation o...