conclusions the addition of 50 mg of magnesium sulfate to a bupivacaine–fentanyl solution for intrathecal anesthesia improved the efficacy and duration of the analgesia without any significant side effects. the addition of 150 µg of neostigmine increased the incidence of hypotension, bradycardia, and nausea and vomiting. moreover, neostigmine failed to prolong analgesia duration. results group ...

Abstract Objective To systematically review the evidence for intrathecal or intraventricular plus intravenous administration of antibiotics compared with standard management postsurgical meningitis ventriculitis. Methods The following databases were searched: MEDLINE, Central Register Controlled Trials (CENTRAL); PubMed, EMBASE; and reference list articles. Results Administration intrathecal/in...

intrathecal injection of sufentanil with adrenalin was performed in 45 cases (20 female, 25 male age range: 18-40 years). all injections were performed in the sitting position, with a number 20 intrathecal needle immersed in adrenalin. the cases were observed for 72 hours. maximum duration of analgesia was 12 hours (60%) and the minimum was 3 hours (13.3%). this method reduces the need for repe...

conclusions conservative management is successful in the vast majority of patients with spinal headache. interventional procedures are required in a small fraction of patients for symptomatic relief. case presentation intrathecal drug delivery system (idds) was initially used for the management of chronic malignant pain; it has since been used to manage pain from other nonmalignant conditions a...

among patients with chronic unrelieved pain, war veterans of eight years long iraq - iran war deserve especial attention. they not only suffer from severe intractable pain but also should bear some intangible consequences of unrelieved pain and severe disability. this perspective study reviews the outcome of implantation of intrathecal opioid pumps in these patients. ten war veterans (mean age ...

BACKGROUND Intrathecal opioid administration has been used widely in patients suffering from severe cancer pain that is not managed with conventional modalities. However, the potential serious neurological complications from the procedure and the side effects of intrathecal opioids have made many clinicians reluctant to employ continuous intrathecal analgesia as a first-line therapeutic option ...

intrathecal administration of midazolam has been reported to have antinociceptive action, and to be an effective analgesic agent. in this prospective double-blind study we aimed to evaluate the postoperative effects of intrathecal midazolam with lidocaine following perineal operation. forty patients were randomly allocated to two groups: 20 patients in the control group received 2 ml of 5% heav...

BACKGROUND Intrathecal administration of acetylcholinesterase inhibitors produces antinociception in both animals and humans, but their effect on diabetic neuropathic pain has not been studied. In the current study, we determined the antiallodynic effect of intrathecal injection of an acetylcholinesterase inhibitor, neostigmine, in a rat model of diabetic neuropathic pain. In addition, since ac...

BACKGROUND Nonsteroidal antiinflammatory drugs are commonly used to treat postoperative and chronic pain. Animal studies suggest that these drugs act, in part, by blocking prostaglandin production in the spinal cord. The authors tested intrathecal ketorolac in patients with chronic or postoperative pain. METHODS After approval of the institutional review board and the Food and Drug Administra...