silver nanoparticles are increasingly used in various fields of biotechnology and applications in the medicine. objectives of this study were optimization of production of silver nanoparticles using biotransformations by fusarium oxysporum, and a further study on the location of nanoparticles synthesis in this microorganism. the reaction mixture contained the following ingredients (final concen...

introduction: anethole is the main constituent of pimpinella anisum l. (anise), a herbaceous annual plant which has several therapeutic effects. in the folk medicine, anise is employed as an antiepileptic drug. specifically, this study was focused on the cellular effect of anethole, an aromatic compound in essential oils from anise and camphor. anethole has various physiological effects on the ...

objective: the brucella melitensis virb operon, encoding a type iv secretion system (t4ss), is required for intracellular replication and persistent infection in the mouse model. the product of the second gene of the virb operon, virb2, is predicted to be localized at the bacterial surface, where they could potentially interact with host cells. studies to date have focused on characterization o...

abstract background: understanding the electrophysiological effects of toxins, may facilitate new drugs discovery. buthotusschach (bs) has been shown to be one of the most dangerous scorpions in tropical part of iran. present study was aimed to investigate the electrophysiological effects of two active fractions (f4 and f6) isolated from bs scorpion toxin on action potential (ap) characteristic...

abstractin the present work we set out to investigate the neuroprotective effects of noscapine (0.5-2 µm) in presence of d-glucose on primary murine foetal cortical neurons after oxygen–glucose deprivation/24 hrs recovery. cell viability, nitric oxide production and intracellular calcium ([ca2+]i) levels were evaluated by mtt assay, the modified griess method and fura-2 respectively. 25 and 100...

l-asparaginase has remarkable properties which make it useful in dual pharmaceutical and food industries.in this study, simple and advantageous method has been validated for rapid and precise determination of intracellular l-asparaginasein bacterial species. a suspension of bacterial cells was used instead ofcell extract and incubated by substrate (asparagine) after simple wash and centrifugati...

conclusions core-lds interaction may be an underlying molecular mechanism to induce liver steatosis in patients with hcv infection. this interaction is also crucial for efficient viral replication and persistence in infected cells. steatosis can also interfere with efficient standard interferon therapy treatment. management of steatosis should be considered along with standard care for achievin...

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Saquinavir exhibits paradoxical transport across modified Caco-2 cell monolayers (doi: 10.1124/jpet.103.056390) expressing P-glycoprotein and Cyp3A4. The data implicate complicated intracellular transport mechanisms. Drawing on recent discrete event modeling and simulation advances, we built an in silico analog of the confluent, asymmetric cell monolayer used in the cited work. We call it in si...

magnesium (mg) is the second most abundant intracellular cation and is involved in numerous physiological functions, including protein folding, intracellular signaling and enzyme catalysis. it has been shown that magnesium deficiency exacerbates pulmonary airways hyperreactivity. several studies suggest that magnesium level has no effect on asthma but others had shown a contributory effect. bec...