objective: to determine the preventive effects of local administration of simvastatin for postoperative intra-abdominal adhesion formation in animal model of rat . methods: in this experimental study, 32 wistar albino rats as the animal model of intra-abdominal adhesion formation were included. adhesions were induced in all the animals via abrasion of the peritoneal and intestinal surface durin...

the objective of this study was to determine the effectiveness of topical administration of honey in prevention of or reduction in post-surgical peritoneal adhesions in dog. the study was conducted on 18 adultfemale mixed-breed dogs with a mean ± sd weight of 20 ± 4.25 kg. a standardized surgical trauma (serosaltrauma model) was made in the dogs’ descending colon to induce adhesion formation. t...

introduction: opium addiction can change immune response to types of stress such as injury or trauma due to alterations in the in secretion status of cytokines in the body. in this study, effects of opium addiction on wound healing and post-operative adhesion bands were assessed after laparotomy. materials and methods: male rats (n=20) were randomly divided into opium addicted (documented with ...

Introduction: Opium addiction can change immune response to Types of stress such as injury or trauma due to alterations in the in secretion status of cytokines in the body. In this study, effects of opium addiction on wound healing and post-operative adhesion bands were assessed after laparotomy. Materials and Methods: Male rats (n=20) were randomly divided into opium addicted (documented with ...

Statin Use at Intra-abdominal Surgery and Postoperative Adhesion-Related Complications Small-Bowel Obstruction

BACKGROUND Postoperative intra-abdominal adhesions are common complications after abdominal surgery. The exact molecular mechanisms that are responsible for these complications remain unclear, and there are no effective methods for preventing adhesion formation or reformation. The aim of the study reported here was to investigate the preventive effects and underlying potential molecular mechani...

The objective of this study was to determine the effectiveness of topical administration of honey in prevention of or reduction in post-surgical peritoneal adhesions in dog. The study was conducted on 18 adultfemale mixed-breed dogs with a mean ± SD weight of 20 ± 4.25 kg. A standardized surgical trauma (serosaltrauma model) was made in the dogs’ descending colon to induce adhesion formation. T...

BACKGROUND Carbon dioxide pneumoperitoneum induces peritoneal oxidative stress. The aim of this study was to verify the effect of intra-abdominal pressure on oxidative stress in the peritoneum and on post-operative adhesion formation. METHODS Forty-one rabbits underwent laparoscopic surgery: either gasless, or with CO(2)-pneumoperitoneum at pressures of 5, 10 or 15 mmHg. Serial parietal perit...