objective(s) human umbilical cord blood (hucb) is now considered as a valuable source for stem cell–based therapies. previous studies showed that intravascular injection of the hucb significantly improves neurological functional recovery in a rat model of intracerebral hemorrhage (ich). in the present study, we hypothesize transplanted hucb derived mononuclear cells (uc-mcs) can decrease injure...

BACKGROUND Hemorrhage volume is an important predictor of outcome in patients with intracerebral hemorrhage (ICH). It is not clear why in some patients ICH volume is larger than in others. Identification of modifiable factors responsible for large-volume hemorrhage in hypertensive patients may help to reduce ICH-related morbidity and mortality. OBJECTIVE The objective of this study was to ide...

BACKGROUND AND PURPOSE Limited data suggest that intracerebral hemorrhage related to oral anticoagulant therapy (OAT ICH) is associated with more hemorrhage expansion and a worse prognosis than spontaneous ICH (SICH). METHODS We examined patients enrolled in the placebo arm of the CHANT study, a prospective randomized trial of a putative neuroprotectant in patients with ICH. All patients had ...

BACKGROUND AND PURPOSE We report an exploratory analysis from a randomized study of recombinant activated factor VII (rFVIIa) in patients with intracerebral hemorrhage (ICH) examining potential factors associated with hemorrhage growth. METHODS We explored the relationship between 5 different measures of change in hemorrhage volume between baseline and 24-hour CTs (absolute and percent change...

OBJECTIVE The purpose of this study was to differentiate between cerebral amyloid angiopathy (CAA) and hypertension (HTN) based on hemorrhage pattern interpretation. METHODS From June 1994 to Oct., 2000, 83 patients admitted to our service with acute intracerebral hemorrhage (ICH) were investigated retrospectively; 41 patients with histologically proven diagnosis of cerebral amyloid angiograp...

BACKGROUND Intracranial hemorrhage (ICH) is the second leading cause of mortality in patients with acute myeloid leukemia (AML). However, the prognostic factors for ICH in AML patients are still under investigation. PATIENTS AND METHODS A total of 841 AML patients admitted to the Department of Internal Medicine from January 1995 to December 2007 were enrolled in this study. RESULTS There we...

Cerebrovascular autoregulation may be dysfunctional after acute intracerebral hemorrhage (ICH). This disruption in autoregulation can potentially result in secondary neurological damage that may present as an intracranial hemorrhage at locations distant from the primary site of hemorrhage. We discuss a case of 68-year-old female who presented with acute left hemiparesis from a spontaneous right...

Spontaneous intracerebral hemorrhage accounts for 4–5% of cases of acute stroke and is associated with a substantially worse prognosis than ischemic stroke. Spontaneous intracerebral hemorrhage is associated with a high mortality rate, almost 50%. Intracranial hemorrhages associated with oral anticoagulants can be divided into intracerebral, subdural/epidural, and subarachnoid. ICH constitutes ...

BACKGROUND AND PURPOSE Although intracerebral hemorrhage (ICH) volume and location are important predictors of outcome in adults, few data exist in children. METHODS A consecutive cohort of children, including full-term newborns to those younger than 18 years of age with nontraumatic, acute ICH and head CT available for analysis were studied. Clinical information was abstracted via chart revi...

BACKGROUND Clinical characteristics and outcomes of intracranial hemorrhage (ICH) among adult patients with various hematological malignancies are limited. METHODS A total of 2,574 adult patients diagnosed with hematological malignancies admitted to a single university hospital were enrolled into this study between 2001 and 2010. The clinical characteristics, image reports and outcomes were r...