objective: in ventricular arrhythmias, due to their free radical scavenging action, antioxidant agents are usually used in the treatment of cardiovascular disease. since stress is considered as risk factor for increased mortality by causing malignant arrhythmias, the study was designed to evaluate the cardioprotective effects of ellagic acid (ea) on cacl2-induced arrhythmias in rat stress model...

introduction: it was shown in a previous study, that mcpip, a cilostamide derivative, increased atrial contraction force without changing contraction rate. to improve this property, two new derivatives of cilostamide were synthesized and their effects on pde3 activity and isolated rat atria contraction were investigated. methods: the inhibitory effect of each compound on pde3 enzyme was determi...

The inotropic agent in the context of heart failure and angina is classified into positive and negative inotropic agent. The positive agent increases the contractility and will be discussed in detail in this article. A brief about the negative inotropic agent, which decreases the myocardial contractility, is mentioned. The inotropic agent, when mentioned alone without any prefix, stands for a p...

myocardial dysfunction is a major complication in cardiac surgery that needs inotropic support. this study evaluates the effect of milrinone on patients with low ventricular ejection fraction undergoing off- pump coronary artery bypass graft (opcab). the present study is designed to evaluate the effect of milrinone on myocardial dysfunction. eighty patients with low ventricular ejection fractio...

The inotropic agent in the context of heart failure and angina is classified into positive and negative inotropic agent. The positive agent increases the contractility and will be discussed in detail in this article. A brief about the negative inotropic agent, which decreases the myocardial contractility, is mentioned. The inotropic agent, when mentioned alone without any prefix, stands for a p...

a,-Adrenoceptor stimulation of rat left ventricular papillary muscles by phenylephrine in the presence of propranolol resulted in rapid breakdown of phosphatidylinositol 4,5-bisphosphate (PI-4,5-Pj) and a triphasic inotropic response in a concentration-dependent manner. The release of inositol trisphosphate (IP,) was maximum within 30 seconds and remained high for at least 30 minutes. The IP3 f...

alpha 1-Adrenoceptor stimulation of rat left ventricular papillary muscles by phenylephrine in the presence of propranolol resulted in rapid breakdown of phosphatidylinositol 4,5-bisphosphate (PI-4,5-P2) and a triphasic inotropic response in a concentration-dependent manner. The release of inositol trisphosphate (IP3) was maximum within 30 seconds and remained high for at least 30 minutes. The ...

The purpose of our study was to investigate the inotropic response to the endogenous agonist norepinephrine mediated through alpha-1 adrenoceptors and to compare this response to that mediated through beta-adrenoceptors in failing human ventricular myocardium. We studied ex vivo the inotropic effect of norepinephrine in isometrically contracting trabecular myocardium from both ventricles of exp...