novel analogues of n-piperazinyl fluoroquinolones were prepared and evaluated against a panel of gram-positive and gram-negative bacteria, to study the effect of introducing bulky anthracene and phenanthrene moieties on the antibacterial effects of norfloxacin, ciprofloxacin and gatifloxacin. although most of the novel synthesized compounds had lower antibacterial effects, some derivatives show...

Background: Despite the availability of a wide range of antibiotics, bacterial infections are among important challenges for the healthcare system. Therefore, the introduction of new antimicrobial preparations such as platelet-rich plasma (PRP) could be suggested theoretically as a preventive measure for bacterial infections. We aimed to evaluate the in vitro antibacterial activity of PRP again...

background: mentha piperita l. essential oils have different antibacterial activity. in the present study, we investigated the effect of γ–irradiation on the antibacterial activities of mentha piperita l. essential oils in vitro and in vivo systems. materials and methods: the aerial parts of peppermint were irradiated in a cobalt60 source with 0, 10 and 25 kgy absorbed doses. then, the plants w...

Background: Mentha piperita L. essential oils have different antibacterial activity. In the present study, we investigated the effect of &gamma–irradiation on the antibacterial activities of Mentha piperita L. essential oils in vitro and in vivo systems. Materials and Methods: The aerial parts of peppermint were irradiated in a cobalt60 source with 0, 10 and 25 kGy absorbed doses. Then, t...

Background: Levan or fructan, a polysaccharide of fructose, is widely used in various commercial industries. Levan could be produced by many organisms, including plants and bacteria. The cloning of the gene from Bacillus licheniformis, which expressed levansucrase in E. coli host, was carried out successfully.  In the present study, we performed the in vitro production of levan and analyzed its...

the resistance of antimicrobials has become a global hazard with the irrational use of antibiotics. infection of drug-resistance bacteria seriously threatens human health. currently there is an urgent need for the development of novel antimicrobial agents with new mechanisms and lower levels of toxicity. in this paper, a series of (s,z)-4-methyl-2-(4-oxo-5-((5-substitutedphenylfuran-2-yl) methy...

non-steroidal anti-inflammatory drugs (nsaids) have shown antibacterial activity in some recent studies. the aim of this study was to evaluate the antibacterial effect of diclofenac against enterococcus faecalis (e. faecalis) as a resistant endodontic bacterium in comparison with ibuprofen, calcium hydroxide and amoxicillin.the antibacterial activity of materials was evaluated using agar diffus...

background and objectives: dental caries is still remained as a major health problem. this problem has created a new interest to search for new antimicrobial agents from various sources including medicinal plants. since limited data is available so far regarding the antibacterial effect of coriandrum sativum seed and dentol drop against streptococcus mutans, this study aims to assess this activ...

honey has antibacterial activity. the aim of this study was to evaluate the antibacterial activity of honey on streptococcus mutans and lactobacillus.in this in vitro study, solutions containing 0%, 5%, 10%, 20%, 50% and 100%(w/v) of natural hamadan honey were prepared. each blood (nutrient) agar plate was then filled with dilutions of the honey. the strains of bacteria were inoculated in blood...